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首页> 外文期刊>Journal of mass spectrometry: JMS >The application of carbon isotope ratio mass spectrometry to doping control
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The application of carbon isotope ratio mass spectrometry to doping control

机译：碳同位素比质谱法在掺杂控制中的应用

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摘要

The administration of synthetic steroid copies is one of the most important issues facing sports. Doping control laboratories accredited by the World Anti-Doping Agency (WADA) require methods of analysis that allow endogenous steroids to be distinguished from their synthetic analogs in urine. The ability to measure isotope distribution at natural abundance with high accuracy and precision has increased the application of Gas Chromatography- Combustion-Isotope Ratio Mass Spectrometry (GC-C-IRMS) to doping control in recent years. GC-C-IRMS is capable of measuring the carbon isotope ratio (delta C-13) of urinary steroids and confirm their synthetic origin based on the abnormal C-13 content. This tutorial describes some of the complexities encountered by obtaining valid delta C-13 measurements from GC-C-IRMS and the need for careful interpretation of all relevant information concerning an individual's metabolism in order to make an informed decision with respect to a doping violation.
机译：合成类固醇复制品的管理是运动面临的最重要问题之一。获得世界反兴奋剂机构（WADA）认可的兴奋剂控制实验室要求采用分析方法，使尿中的内源性类固醇与合成的类固醇区分开来。近年来，在自然丰度下以高精度和高精度测量同位素分布的能力增加了将气相色谱-燃烧-同位素比质谱（GC-C-IRMS）应用于掺杂控制的应用。 GC-C-IRMS能够测量尿类固醇的碳同位素比（δC-13），并根据异常的C-13含量确定其合成来源。本教程描述了从GC-C-IRMS获得有效的C-13增量测量值时遇到的一些复杂性，以及需要仔细解释与个人新陈代谢有关的所有相关信息以便就掺杂违规做出明智决定的必要性。

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