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首页> 外文期刊>Journal of mass spectrometry: JMS >Generation of picoliter droplets of liquid for electrospray ionization with piezoelectric inkjet
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Generation of picoliter droplets of liquid for electrospray ionization with piezoelectric inkjet

机译：用压电喷墨产生皮微升液滴进行电喷雾电离

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摘要

We report the association of inkjet and electrospray ionization MS to detect picoliter droplet, where the liquid volume and its position onto the tip can be precisely controlled to form ultrafine droplets for successive ionization of the analyte. Single rectangle pulse was applied to piezoelectric device on inkjet microchip for the ejection of each picoliter droplet, and it was controlled by a computer. The voltage and width of driving pulse for the inkjet were optimized to make reproducible ejection of the solvent with low viscosity. The volume of each droplet was about 600 pl, and a trigger of 10 droplets was selected as the best inlet mode taking relative standard derivation of the droplets into consideration. The target substrate used with high voltage to form ionization was graphite, after several attempts with some materials. High-speed camera was used to capture the breaking-up process of a droplet. The distance between the inkjet nozzle and the tip was set at 2 cm to avoid short circuit. The influences on the mass intensity of the diameter of the tip, the volume and the concentration of the sample were examined. The tip with a small diameter performed greater intensity, and the limit of detection decreased, whereas the small volume of liquid played high ionization efficiency. Linear regression in the range between 1 and 200 ppm for caffeine was conducted, where internal standard theobromine was used. Some real samples were also detected with the instrument.
机译：我们报告了喷墨和电喷雾离子化MS的关联，以检测微微升液滴，其中可以精确控制液体的体积及其在尖端上的位置，以形成用于分析物连续电离的超细液滴。将单个矩形脉冲施加到喷墨微芯片上的压电装置上，以喷射每个皮升液滴，并由计算机控制。优化了喷墨的电压和驱动脉冲宽度，以使可再现性的低粘度溶剂喷射得以实现。每个液滴的体积约为600 pl，并考虑到液滴的相对标准推导，选择10个液滴作为最佳的进样方式。在对某些材料进行了几次尝试之后，用于高压以形成离子化的目标衬底是石墨。使用高速相机捕获液滴的破碎过程。喷墨喷嘴和喷嘴之间的距离设置为2 cm，以避免短路。检查了对尖端直径的质量强度，样品的体积和浓度的影响。直径小的尖端强度更大，检测极限降低，而小体积的液体则具有较高的电离效率。在使用内标可可碱的情况下，对咖啡因进行了介于1至200 ppm之间的线性回归。该仪器还检测到一些真实样品。

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