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首页> 外文期刊>Journal of mass spectrometry: JMS >Efficiency of the dry-wet method for the MALDI-MSI analysis of latent fingermarks
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Efficiency of the dry-wet method for the MALDI-MSI analysis of latent fingermarks

机译：干湿法对潜在指印进行MALDI-MSI分析的效率

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摘要

Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) has proven to be a powerful analytical tool to investigate problems in several fields of life science. A novel application is in the field of forensics, particularly in the analysis of latent fingermarks. This technology enables images of the fingermark ridge detail and additional intelligence to be simultaneously obtained. Although several methods are available to deposit the MALDI matrix, to make the technology forensically operational, another deposition approach was devised and reported, namely the 'dry-wet' method. In the present study, the efficiency of the dry-wetmethod was evaluated and compared with the conventional spray coat methodology. Results indicate that the dry-wet method is superior for all the donors' typologies in terms of ion signal intensity and clarity of the ridge details. To underpin the reasons of this efficiency, scanning electron microscopy analyses were carried out in parallel to MALDI-MSI experiments using matrices of different particle size. Results have confirmed that the particle size plays an important role in the efficiency of the method as higher quality images and higher intensity spectra are produced as the matrix particle size decreases.
机译：基质辅助激光解吸/电离质谱成像（MALDI-MSI）已被证明是研究生命科学多个领域问题的强大分析工具。一种新颖的应用在取证领域，特别是在潜在指印的分析中。这项技术可以同时获取指尖脊细节的图像和其他智能。尽管有几种方法可以沉积MALDI基质，但要使该技术具有法医意义，则已设计并报道了另一种沉积方法，即“干湿”法。在本研究中，对干湿法的效率进行了评估，并与常规喷涂方法进行了比较。结果表明，就离子信号强度和山脊细节的清晰度而言，干湿法对所有供体的类型均优于。为了支持此效率的原因，使用不同粒径的基质，与MALDI-MSI实验并行进行了扫描电子显微镜分析。结果证实，随着基质粒径的减小，产生更高质量的图像和产生更高的强度光谱，粒径在该方法的效率中起着重要作用。

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