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首页> 外文期刊>Journal of mass spectrometry: JMS >Sodium adduct formation efficiency in ESI source
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Sodium adduct formation efficiency in ESI source

机译：ESI源中钠加合物的形成效率

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摘要

Formation of sodium adducts in electrospray (ESI) has been known for long time, but has not been used extensively in practice, and several important aspects of Na~+ adduct formation in ESI source have been almost unexplored: the ionization efficiency of different molecules via Na~+ adduct formation, its dependence on molecular structure and Na+ ion concentration in solution, fragmentation behaviour of the adducts as well as the ruggedness (a prerequisite for wider practical use) of ionization via Na~+ adduct formation. In this work, we have developed a parameter describing sodium adducts formation efficiency (SAFE) of neutral molecules and have built a SAFE scale that ranges for over four orders of magnitude and contains 19 compounds. In general, oxygen bases have higher efficiency of Na~+ adducts formation than nitrogen bases because of the higher partial negative charge on oxygen atoms and competition from protonation in the case of nitrogen bases. Chelating ability strongly increases the Na~+ adduct formation efficiency.We show that not only protonation but also Na~+ adduct formation is a quantitative and reproducible process if relative measurements are performed.
机译：在电喷雾（ESI）中钠加合物的形成已为人所知，但在实践中并未得到广泛使用，而且在ESI源中Na〜+加合物形成的几个重要方面也几乎未得到开发：不同分子的电离效率通过Na〜+加合物的形成，其对分子结构和溶液中Na +离子浓度的依赖性，加合物的断裂行为以及通过Na〜+加合物形成的电离的坚固性（更广泛的实际应用的前提）。在这项工作中，我们开发了一个描述中性分子钠加合物形成效率（SAFE）的参数，并建立了一个SAFE标度，范围超过四个数量级，包含19种化合物。通常，由于氧原子上较高的部分负电荷和在氮碱情况下的质子竞争，所以氧碱比氮碱具有更高的Na〜+加合物形成效率。螯合能力极大地提高了Na〜+加合物的形成效率。我们表明，如果进行相对测量，不仅质子化而且Na〜+加合物的形成都是定量且可重现的过程。

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