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首页> 外文期刊>Journal of mass spectrometry: JMS >Gas chromatography-mass spectrometry with supersonic molecular beams
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Gas chromatography-mass spectrometry with supersonic molecular beams

机译：超声分子束气相色谱-质谱联用

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Gas chromatography-mass spectrometry (GC-MS) with supersonic molecular beams (SMBs) (also named Supersonic GC-MS) is based on GC and MS interface with SMBs and on the electron ionization (ED of vibrationally cold analytes in the SMBs (cold El) in a fly-through ion source. This ion source is inherently inert and further characterized by fast response and vacuum background filtration capability. The same ion source offers three modes of ionization including cold EI, classical EI and cluster chemical ionization (CI). Cold EI, as a main mode, provides enhanced molecular ions combined with an effective library sample identification; which is supplemented and complemented by a powerful isotope abundance analysis method and software. The range of low-volatility and thermally labile compounds amenable for analysis is significantly increased owing to the use of the contact-free, fly-through ion source and the ability to lower sample elution temperatures through the use of high column carrier gas flow rates. Effective, fast GC-MS is enabled particularly owing to the possible use of high column flow rates and improved system selectivity in view of the enhancement of the molecular ion. This fast GC-MS with SMB can be further improved via the added selectivity of MS-MS, which by itself benefits from the enhancement of the molecular ion, the most suitable parent ion for MS-MS. Supersonic GC-MS is characterized by low limits of detection (LOD), and its sensitivity is superior to that of standard GC-MS, particularly for samples that are hard for analysis. The GC separation of the Supersonic GC-MS can be improved with pulsed flow modulation (PFM) GCxGC-MS. Electron ionization LC-MS with SMB can also be combined with the Supersonic GC-MS, with fast and easy switching between these two modes of operation.
机译：具有超音速分子束（SMB）的气相色谱-质谱（GC-MS）（也称为Supersonic GC-MS）基于与SMB的GC和MS接口以及电子电离（SMB中的振动冷分析物的ED（冷离子源固有的惰性，并具有快速响应和真空背景过滤的特性，同一离子源提供三种电离模式，包括冷EI，经典EI和簇化学电离（CI） 。Cold EI作为一种主要模式，可提供增强的分子离子，并具有有效的库样品鉴定功能，并辅以功能强大的同位素丰度分析方法和软件进行补充和补充，适用于分析的低挥发性和热不稳定化合物的范围为由于使用了非接触式飞越离子源，并且通过使用高柱载量ga降低了样品洗脱温度的能力，显着提高了的流量。考虑到分子离子的增强，特别是由于可以使用高色谱柱流速和改进的系统选择性，因此可以实现高效，快速的GC-MS。这种具有SMB的快速GC-MS可以通过增加MS-MS的选择性来进一步改善，这本身就得益于分子离子的增强，分子离子是MS-MS最适合的母离子。超音速GC-MS具有低检测限（LOD）的特点，其灵敏度优于标准GC-MS，特别是对于难以分析的样品。可以使用脉冲流调制（PFM）GCxGC-MS改进Supersonic GC-MS的GC分离。具有SMB的电子电离LC-MS也可以与Supersonic GC-MS结合使用，可以在这两种操作模式之间快速便捷地进行切换。

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