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首页> 外文期刊>Journal of mass spectrometry: JMS >Fundamental properties of a touchable highpower pulsed microplasma jet and its application as a desorption/ionization source for ambient mass spectrometry
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Fundamental properties of a touchable highpower pulsed microplasma jet and its application as a desorption/ionization source for ambient mass spectrometry

机译：可触摸的高功率脉冲微等离子体射流的基本特性及其在环境质谱中作为解吸/电离源的应用

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摘要

Plasma-based ambient desorption/ionization mass spectrometry (ADI–MS) has attracted considerable attention in many fields because of its capacity for direct sample analyses. In this study, a high-power pulsed microplasma jet (HPPMJ) was developed and investigated as a new plasma desorption/ionization source. In an HPPMJ, a microhollow cathode discharge is generated in a small hole (500 μm in diameter) using a pulsed high-power supply. This system can realize a maximum power density of 5×10~8 W/cm~3. The measured electron number density, excitation temperature and afterglow gas temperature of the HPPMJ were 3.7 × 10~(15) cm~(-3), 7000 K at maximum and less than 60 ℃, respectively, which demonstrate that the HPPMJ is a highenergy, high-density plasma source that is comparable with an argon inductively coupled plasma while maintaining a low gas temperature. The HPPMJ causes no observable damage to the target because of its low gas temperature and electrode configuration; thus, we can apply it directly to human skin. To demonstrate the analytical capacity of ADI–MS using an HPPMJ, the plasma was applied to direct solid sample analysis of the active ingredients in pharmaceutical tablets. Caffeine, acetaminophen, ethenzamide, isopropylantipyrine and ibuprofen were successfully detected. Application to living tissue was also demonstrated, and isopropylantipyrine on a finger was successfully analyzed without damaging the skin. The limits of detection (LODs) for caffeine, isopropylantipyrine and ethenzamide were calculated, and LODs at the picogram level were achieved. These results indicate the applicability of the HPPMJ for high-sensitivity analysis of materials on a heat-sensitive surface.
机译：基于等离子体的环境解吸/电离质谱法（ADI-MS）由于可以直接进行样品分析而在许多领域引起了相当大的关注。在这项研究中，开发了高功率脉冲微等离子体射流（HPPMJ），并作为一种新的等离子体解吸/电离源进行了研究。在HPPMJ中，使用脉冲大功率电源在一个小孔（直径为500μm）中产生微空心阴极放电。该系统可以实现5×10〜8 W / cm〜3的最大功率密度。 HPPMJ的实测电子数密度，激发温度和余辉气体温度分别为3.7×10〜（15）cm〜（-3），最高7000 K和低于60℃，表明HPPMJ是高能。在保持较低气体温度的同时，可与氩气感应耦合等离子体相比的高密度等离子体源。 HPPMJ由于其较低的气体温度和电极配置而不会对目标造成明显的损坏;因此，我们可以将其直接应用于人体皮肤。为了证明使用HPPMJ的ADI-MS的分析能力，将血浆用于直接分析药物片剂中活性成分的固体样品。成功检测出咖啡因，对乙酰氨基酚，乙酰胺，异丙基安替比林和布洛芬。还证明了其在生物组织中的应用，并且成功分析了手指上的异丙基安替比林，而不会损坏皮肤。计算了咖啡因，异丙基安替比林和乙酰胺的检出限（LOD），并达到了皮克级的检出限。这些结果表明HPPMJ适用于热敏表面上的材料的高灵敏度分析。

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