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首页> 外文期刊>Journal of mass spectrometry: JMS >Development and validation of a high-resolution LTQ Orbitrap MS method for the quantification of isoflavones in wastewater effluent
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Development and validation of a high-resolution LTQ Orbitrap MS method for the quantification of isoflavones in wastewater effluent

机译：高分辨率LTQ Orbitrap MS方法的开发和验证，用于量化废水中的异黄酮

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摘要

Isoflavones and coumestranes are the most important classes of compounds among phytoestrogens; by binding to estrogen receptors, they mimic or modulate the effect on the endogenous receptors. Little information can be found in literature about the presence of isoflavones and coumestrol in the environment, even if it is known that this may have significance, being these substances classified as endocrine disrupting compounds. In this research, we aim to explore the capabilities of the LTQ Orbitrap Discovery hybrid MS in full-scan acquisition mode, with high resolution, to validate an analytical method for the quantification of nine isoflavones (genistein, genistin, glycitein, daidzein, daidzin, (R,S)-equol, biochanin A, formononetin and coumestrol) in wastewater samples. The correlation coefficients of calibration curves of the nine analyzed compounds were in a range of 0.996-0.999; recoveries at two different levels of concentration (0.05 and 0.5 mu g/l) were in the range 73-98%, and the limits of detection ranged between 0.0014 and 0.017 mu g/l, proving that this method is sensitive enough in comparison with other methods available in literature. This method has been applied for the analysis of 20 wastewater treatment plants in County Cork, Ireland. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：异黄酮和香豆素是植物雌激素中最重要的化合物。通过与雌激素受体结合，它们模拟或调节了对内源性受体的作用。在文献中几乎找不到有关环境中异黄酮和香豆酚存在的信息，即使已知这可能具有重要意义，因为这些物质被归类为内分泌干扰化合物。在这项研究中，我们旨在探索高分辨率的LTQ Orbitrap Discovery混合质谱仪在全扫描采集模式下的功能，以验证一种定量分析九种异黄酮（金雀异黄素，染料木素，糖精，黄豆苷原，大豆苷，废水样品中的（R，S）-雌马酚，生物chanin A，formononetin和coumestrol）。所分析的9种化合物的校正曲线的相关系数在0.996-0.999的范围内。两种不同浓度水平（0.05和0.5μg / l）的回收率在73-98％之间，检出限在0.0014和0.017μg/ l之间，证明了该方法与文献中可用的其他方法。该方法已用于分析爱尔兰科克郡的20个废水处理厂。版权所有（c）2015 John Wiley＆Sons，Ltd.

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