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首页> 外文期刊>Journal of mass spectrometry: JMS >Mass spectrometry detection of minor new meridianins from the antarctic colonial ascidians Aplidium falklandicum and Aplidium meridianum
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Mass spectrometry detection of minor new meridianins from the antarctic colonial ascidians Aplidium falklandicum and Aplidium meridianum

机译：质谱法检测南极殖民海鞘中的次要新子午线植物福克兰和子午线虫

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摘要

Taking into account the broad biological activities found in the meridianin indole alkaloids isolated to date, we have re-examined the organic extracts of an Antarctic collection of the tunicates Aplidium meridianum and A.falklandicum (Chordata: Ascidiacea) by HPLC in conjunction with a high-resolution mass spectrometer (HPLC-MS). A new set of analogs of meridianins A-G has been detected, and their structures are proposed on the basis of the molecular formulae identified by LC-HRMS analysis using a C18 column with a gradient of water/acetonitrile and an LTQ-FT-MS Orbitrap detector. Remarkably, dimers derived from meridianin A and from meridianin B or E were also detected. Our findings provide further evidence of the broad variability within the meridianin-like derivatives of this highly bioactive alkaloid family. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：考虑到迄今为止在子午线吲哚生物碱中发现的广泛生物活性，我们结合高效液相色谱法对HPLC进行了复查，证明了被子植物Aplidium meridianum和A.falklandicum（Chordata：Ascidiacea）的南极集合的有机提取物。分辨率质谱仪（HPLC-MS）。已检测到一组新的子午肽类似物，并基于使用带有水/乙腈梯度的C18色谱柱和LTQ-FT-MS Orbitrap检测器通过LC-HRMS分析鉴定的分子式，提出了其结构。值得注意的是，还检测到了源自子午线A和子午线B或E的二聚体。我们的发现为该高度生物活性生物碱家族的子午线样衍生物内的广泛变异提供了进一步的证据。版权所有（c）2015 John Wiley＆Sons，Ltd.

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