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首页> 外文期刊>Journal of mass spectrometry: JMS >MALDI imaging reveals lipid changes in the skin of leprosy patients before and after multidrug therapy (MDT)
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MALDI imaging reveals lipid changes in the skin of leprosy patients before and after multidrug therapy (MDT)

机译：MALDI成像显示麻风患者在接受多种药物治疗（MDT）之前和之后的皮肤脂质变化

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摘要

Leprosy still represents a health problem in several countries. Affecting skin and peripheral nerves, it may lead to permanent disabilities. Disturbances on skin lipid metabolism in leprosy were already observed; however, the localization and distribution of lipids could not be accessed. The role of lipids on infectious disease has been fully addressed only recently, as they directly influence immune response. Matrix-assisted laser desorption/ionization imaging mass spectrometry provides a powerful tool to localize and identify lipids in tissues. The aim of this work was to study and compare the changes in lipid distribution of skin biopsies taken from leprosy patients before and after multidrug therapy (MDT). Different species of phosphatidic acid, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, sphingomyelin and phosphatidylcholine were detected. Differences in skin lipid signal intensities, as well as in their localization, were observed before and after MDT in every patient. In general, lipid distribution in the skin after MDT had a pattern similar to control skin samples, where most of the lipids were located in the upper part of the dermis and epidermis. This study opens paths to a better understanding of lipid functions in leprosy pathogenesis and immune response. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：麻风病仍然是一些国家的健康问题。影响皮肤和周围神经，可能导致永久性残疾。已经观察到麻风病皮肤脂质代谢紊乱。但是，无法获得脂质的定位和分布。脂质在传染病中的作用直到最近才被完全研究，因为它们直接影响免疫反应。基质辅助激光解吸/电离成像质谱分析提供了一种强大的工具，可以定位和识别组织中的脂质。这项工作的目的是研究和比较麻风患者在多药治疗（MDT）前后皮肤活检组织中脂质分布的变化。检测到不同种类的磷脂酸，磷脂酰乙醇胺，磷脂酰丝氨酸，磷脂酰肌醇，鞘磷脂和磷脂酰胆碱。在每例患者中，MDT前后均观察到皮肤脂质信号强度及其定位的差异。通常，MDT后皮肤中的脂质分布具有类似于对照皮肤样品的模式，其中大多数脂质位于真皮和表皮的上部。这项研究为更好地了解麻风病发病机理和免疫应答中的脂质功能开辟了道路。版权所有（c）2015 John Wiley＆Sons，Ltd.

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