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首页> 外文期刊>Journal of mass spectrometry: JMS >Precise determination of nonlinear function of ion mobility for explosives and drugs at high electric fields for microchip FAIMS
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Precise determination of nonlinear function of ion mobility for explosives and drugs at high electric fields for microchip FAIMS

机译：用于微炸药FAIMS的炸药和药物在高电场下离子迁移率非线性函数的精确测定

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High-field asymmetric waveform ion mobility spectrometry (FAIMS) separates ions by utilizing the characteristics of nonlinear ion mobility at high and low electric fields. Accurate ion discrimination depends on the precise solution of nonlinear relationships and is essential for accurate identification of ion species for applications. So far, all the nonlinear relationships of ion mobility obtained are based at low electric fields (E/N <65 Td). Microchip FAIMS (-FAIMS) with small dimensions has high electric field up to E/N=250 Td, making the approximation methods and conclusions for nonlinear relationships inappropriate for these systems. In this paper, we deduced nonlinear functions based on the first principle and a general model. Furthermore we considered the hydrodynamics of gas flow through microchannels. We then calculated the specific alpha coefficients for cocaine, morphine, HMX, TNT and RDX, respectively, based on their FAIMS spectra measured by -FAIMS system at ultra-high fields up to 250 Td. The results show that there is no difference in nonlinear alpha functions obtained by the approximation and new method at low field (<120 Td), but the error induced by using approximation method increases monotonically with the increase in field, and could be as much as 30% at a field of 250 Td. Copyright (c) 2015 John Wiley & Sons, Ltd.
机译：高场非对称波形离子迁移谱仪（FAIMS）通过利用高和低电场下的非线性离子迁移率特征来分离离子。准确的离子识别取决于非线性关系的精确解，对于准确识别应用中的离子种类至关重要。到目前为止，所有获得的离子迁移率非线性关系都基于低电场（E / N <65 Td）。小尺寸的Microchip FAIMS（-FAIMS）具有高达E / N = 250 Td的高电场，这使得非线性关系的近似方法和结论不适用于这些系统。在本文中，我们基于第一原理和一般模型推导了非线性函数。此外，我们考虑了通过微通道的气流的流体动力学。然后，我们根据-FAIMS系统在高达250 Td的超高场测量的FAIMS光谱，分别计算了可卡因，吗啡，HMX，TNT和RDX的比α系数。结果表明，在低场（<120 Td）下，通过逼近和新方法获得的非线性α函数没有差异，但使用逼近方法引起的误差随场的增加而单调增加，可能高达250 Td时为30％。版权所有（c）2015 John Wiley＆Sons，Ltd.

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