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首页> 外文期刊>Journal of mass spectrometry: JMS >Simplification of electrospray mass spectra of Polysorbate 80 via cation transfer to carborane anions
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Simplification of electrospray mass spectra of Polysorbate 80 via cation transfer to carborane anions

机译：通过阳离子转移至碳硼烷阴离子简化聚山梨酯80的电喷雾质谱

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摘要

Mass spectrometric analysis of polymer mixtures via electrospray ionization can be complicated due the presence of multiple ion types, multiple charge states and multiple oligomeric distributions that complicate the detection and identification of mixture components. Polysorbate 80 (commercially known as Tween((R)) 80) provides an example of this type, where the presence of polyoxyethylene sorbitan monooleate (PSO) byproducts gives rise to overlapping polymer distributions. It is desirable to simplify the spectrum in order to identify each component of what is inherently a complex mixture of fatty esters bound to different head groups. In this work, we show that gas-phase ion/ion reactions with carborane anions allow for the charge reduction of Tween((R)) 80 peaks by selectively removing metal adducts bound to the synthetic polymer. The resulting singly charged spectrum reduces overlapping distributions and thus simplifies the identification of the components found in a Tween((R)) 80 sample. The overall approach described here would likely lead to similar benefits in the analysis of other polymers that tend to ionize via metal ion adduction. Copyright (c) 2016 John Wiley & Sons, Ltd.
机译：通过电喷雾电离对聚合物混合物进行质谱分析可能会很复杂，因为存在多种离子类型，多种电荷状态和多种低聚物分布，这使混合物成分的检测和鉴定变得复杂。聚山梨酯80（商业上称为Tween80）提供了这种类型的例子，其中聚氧乙烯山梨糖醇酐单油酸酯（PSO）副产物的存在引起重叠的聚合物分布。希望简化光谱以便鉴定本质上是结合到不同头基上的脂肪酯的复杂混合物的每种成分。在这项工作中，我们表明与碳硼烷阴离子的气相离子/离子反应可通过选择性除去结合到合成聚合物上的金属加合物来减少Tween（R）80峰的电荷。所得的单电荷谱减少了重叠分布，因此简化了在Tween 80样品中发现的组分的鉴定。此处描述的总体方法可能会在分析其他倾向于通过金属离子加成发生电离的聚合物时带来类似的好处。版权所有（c）2016 John Wiley＆Sons，Ltd.

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