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首页> 外文期刊>Journal of mass spectrometry: JMS >Thermal desorption counter-flow introduction atmospheric pressure chemical ionization for direct mass spectrometry of ecstasy tablets
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Thermal desorption counter-flow introduction atmospheric pressure chemical ionization for direct mass spectrometry of ecstasy tablets

机译：热解吸逆流引入大气压化学电离用于摇头丸的直接质谱

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摘要

A novel approach to the analysis of ecstasy tablets by direct mass spectrometry coupled with thermal desorption (TD) and counter-flow introduction atmospheric pressure chemical ionization (CFI-APCI) is described. Analytes were thermally desorbed with a metal block heater and introduced to a CFI-APCI source with ambient air by a diaphragm pump. Water in the air was sufficient to act as the reactive reagent responsible for the generation of ions in the positive corona discharge. TD-CFI-APCI required neither a nebulizing gas nor solvent flow and the accompanying laborious optimizations. Ions generated were sent in the direction opposite to the air flow by an electric field and introduced into an ion trap mass spectrometer. The major ions corresponding to the protonated molecules ([M + H](+)) were observed with several fragment ions in full scan mass spectrometry (MS) mode. Collision-induced dissociation of protonated molecules gave characteristic product-ion mass spectra and provided identification of the analytes within 5 s. The method required neither sample pretreatment nor a chromatographic separation step. The effectiveness of the combination of TD and CFI-APCI was demonstrated by application to the direct mass spectrometric analysis of ecstasy tablets and legal pharmaceutical products.
机译：描述了一种通过直接质谱联用热脱附（TD）和逆流引入大气压化学电离（CFI-APCI）来分析摇头丸的新颖方法。用金属块加热器对分析物进行热脱附，并通过隔膜泵将其与环境空气一起引入CFI-APCI源。空气中的水足以充当负责在正电晕放电中产生离子的反应试剂。 TD-CFI-APCI既不需要雾化气体，也不需要溶剂，也不需要费力的优化工作。产生的离子通过电场沿与气流相反的方向发送，并引入离子阱质谱仪。在全扫描质谱（MS）模式下，用几个碎片离子观察到了与质子化分子（[M + H]（+））相对应的主要离子。碰撞诱导的质子化分子解离给出了特征性的产物离子质谱，并在5 s内鉴定了分析物。该方法既不需要样品预处理也不需要色谱分离步骤。 TD和CFI-APCI组合的有效性通过将其用于摇头丸和合法药品的直接质谱分析中得到了证明。

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