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首页> 外文期刊>Journal of mass spectrometry: JMS >Formation of the unusual [M+H-11 Da](+) ion peak in the collision-induced dissociation mass spectrum of [M+H](+) ion of hydrochlorothiazide
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Formation of the unusual [M+H-11 Da](+) ion peak in the collision-induced dissociation mass spectrum of [M+H](+) ion of hydrochlorothiazide

机译：氢氯噻嗪[M + H]（+）离子碰撞诱导解离质谱中异常[M + H-11 Da]（+）离子峰的形成

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摘要

Hydrochlorothiazide (HCT) is one of the diuretics that is banned in sport by the World Anti-Doping Agency (WADA). In continuation of our diuretics confirmation work for anti-doping purposes, the tandem mass (MS/MS) spectrum of the HCT under low-energy collision-induced dissociation (CID) mass spectrometry with positive electrospray ionization (ESI) was investigated and interpreted in detail. The CID of the protonated HCT at m/z 298 generated the unexpected product ion at m/z 287 corresponding to the [M+H-11 Da]+ ion of HCT on a 3Dion trap mass spectrometer (MS). Although it is well known that ions undergo gas-phase rearrangements under low-energy CID conditions, the formation of this unexpected product ion could not be easily explained by the conventional mechanism.[1–8] Therefore, the aim of the present study is essentially to rationalize the uncommon behavior resulting in the unusual [M+H-11 Da]+ ion peak under the lowenergy CID.
机译：氢氯噻嗪（HCT）是世界反兴奋剂机构（WADA）在运动中禁止使用的利尿剂之一。在继续我们的利尿药确证工作以用于反兴奋剂方面，研究人员在低能碰撞诱导离解（CID）质谱与正电喷雾电离（ESI）的条件下研究了HCT的串联质谱（MS / MS）。详情。在3Dion阱质谱仪（MS）上，质子化的HCT的CID在m / z 298处在m / z 287处生成了意外的产物离子，该离子对应于HCT的[M + H-11 Da] +离子。尽管众所周知，离子在低能CID条件下会发生气相重排，但是用常规机理很难解释这种意外产物离子的形成。[1-8]因此，本研究的目的是实质上是为了合理化这种不常见的行为，从而在低能CID下产生不寻常的[M + H-11 Da] +离子峰。

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