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首页> 外文期刊>Journal of mass spectrometry: JMS >Fragmentation pathways of metopimazine and its metabolite using ESI-MSn, HR-MS and H/D exchange
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Fragmentation pathways of metopimazine and its metabolite using ESI-MSn, HR-MS and H/D exchange

机译：使用ESI-MSn，HR-MS和H / D交换的美托咪嗪及其代谢物的裂解途径

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摘要

Metopimazine (MPZ) is a phenothiazine derivative used to prevent emesis during chemotherapy where few structural analysis of the aforementioned compound have been described in the literature. Thus, this work reports, for the first time, the detailed study of fragmentation pathways of MPZ and its metabolite (AMPZ) using electrospray ionization (EI) with multistage mass spectrometry (ESI-MSn) in positive-ion mode. The structures of 21 product ions were identified and their accurate masses were determined using high resolution mass spectrometry (HRMS) experiments. Characteristic product ions of these two phenothiazine derivatives are more particularly displayed along with differences between their relative abundances and their structures checked by H/D exchange experiments.
机译：美托咪嗪（MPZ）是一种吩噻嗪衍生物，用于预防化疗期间的呕吐，文献中很少描述上述化合物的结构。因此，这项工作首次报道了在正离子模式下使用电喷雾电离（EI）和多级质谱（ESI-MSn）对MPZ及其代谢物（AMPZ）的裂解途径进行的详细研究。鉴定了21种产物离子的结构，并使用高分辨率质谱（HRMS）实验确定了其准确质量。这两种吩噻嗪衍生物的特征产物离子以及它们的相对丰度和通过H / D交换实验检查的结构之间的差异将更特别地展示出来。

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