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首页> 外文期刊>Journal of mass spectrometry: JMS >Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds
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Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds

机译：监测可能含有合成大麻素作为精神活性化合物的草药混合物

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Herbal mixtures like ‘Spice’ with potentially bioactive ingredients were available in many European countries since 2004 and are still widely used as a substitute for cannabis, although merchandized as ‘herbal incense’. After gaining a high degree of popularity in 2008, big quantities of these drugs were sold. In December 2008, synthetic cannabinoids were identified in the mixtures which were not declared as ingredients: the C8 homolog of the non-classical cannabinoid CP-47,497 (CP-47,497-C8) and a cannabimimetic aminoalkylindole called JWH-018. In February 2009, a few weeks after the German legislation put these compounds and further pharmacologically active homologs of CP-47,497 under control, another cannabinoid appeared in ‘incense’ products: the aminoalkylindole JWH-073. In this paper, the results of monitoring of commercially available ‘incense’ products from June 2008 to September 2009 are presented. In this period of time, more than 140 samples of herbal mixtures were analyzed for bioactive ingredients and synthetic cannabimimetic substances in particular. The results show that the composition of many products changed repeatedly over time as a reaction to prohibition and prosecution of resellers. Therefore neither the reseller nor the consumer of these mixtures can predict the actual content of the ‘incense’ products. As long as there is no possibility of generic definitions in the controlled substances legislation, further designer cannabinoids will appear on the market as soon as the next legal step has been taken. This is affirmed by the recent identification of the aminoalkylindoles JWH-250 and JWH-398. As further cannabinoids can be expected to occur in the near future, a continuous monitoring of these herbal mixtures is required. The identification of the synthetic opioid O-desmethyltramadol in a herbal mixture declared to contain ‘kratom’ proves that the concept of selling apparently natural products spiked with potentially dangerous synthetic chemicals/pharmaceuticals is a continuing trend on the market of ‘legal highs’.
机译：自2004年以来，欧洲许多国家/地区都在使用诸如“香料”之类的具有潜在生物活性成分的草药混合物，尽管被商品化为“草药香”，但它们仍被广泛用作大麻的替代品。在2008年获得高度欢迎之后，大量出售了这些药物。 2008年12月，在未宣布为成分的混合物中鉴定出合成大麻素：非经典大麻素CP-47,497（CP-47,497-C8）的C8同源物和名为JWH-018的大麻素氨基烷基吲哚。 2009年2月，在德国立法将这些化合物以及CP-47,497的进一步药理活性同系物控制在几周后，“香”产品中出现了另一种大麻素：氨基烷基吲哚JWH-073。本文介绍了从2008年6月到2009年9月对市售“香”产品的监控结果。在这段时间里，分析了140多种草药混合物样品的生物活性成分，尤其是合成的拟大麻素。结果表明，许多产品的成分随着时间的推移反复变化，这是对经销商的禁止和起诉的一种反应。因此，经销商和这些混合物的消费者都无法预测“香”产品的实际含量。只要在受控物质立法中没有通用定义的可能性，一旦采取下一法律步骤，更多的设计师大麻素将出现在市场上。氨基烷基吲哚JWH-250和JWH-398的最新鉴定证实了这一点。由于预计在不久的将来还会出现更多的大麻素，因此需要对这些草药混合物进行连续监测。在宣称含有“ kratom”的草药混合物中鉴定出合成的阿片类药物O-去甲基曲马多，证明了销售带有潜在危险的合成化学品/药品的天然表观产品的概念一直是“合法高价”市场上的持续趋势。

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