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首页> 外文期刊>Journal of mass spectrometry: JMS >Ion trap mass analysis at high pressure: an experimental characterization
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Ion trap mass analysis at high pressure: an experimental characterization

机译：高压离子阱质量分析：实验表征

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摘要

In recent years, it has become increasingly interesting to understand the performance of mass spectrometers at pressures much higher than those employed with conventional operating conditions. This interest has been driven by several influences, including demand for the development of reduced-power miniature mass spectrometers, desire for improved ion transfer into and through mass spectrometers, enhanced-yield preparative mass separations, and mass filtering at the atmospheric pressure interface. In this study, an instrument was configured to allow for the performance characterization of a rectilinear ion trap (RIT) at pressures up to 50 mtorr with air used as the buffer gas. The mass analysis efficiency, mass resolution, isolation efficiency, and collision-induced dissociation (CID) efficiency were evaluated at pressures ranging from 1 to 50 mtorr. The extent of degradation of mass resolution, isolation efficiency and ion stability as functions of pressure were characterized. Also, the optimal resonance ejection conditions were obtained at various pressures. Operations at 50 mtorr demonstrated improved CID efficiency in addition to peak widths of 2 and 5 m/z units (full width at half-maximum, FWHM) for protonated caffeine (m/z 195) and Ultramark (m/z 1521) respectively.
机译：近年来，了解质谱仪在比常规操作条件下使用的压力高得多的压力下的性能变得越来越有趣。这种兴趣受到多种影响的驱使，包括对开发低功耗微型质谱仪的需求，对改善离子进入质谱仪和通过质谱仪的离子传递，提高产率的制备型质量分离以及在大气压界面进行质量过滤的需求。在这项研究中，配置了一种仪器以允许在高达50 mtorr的压力下使用空气作为缓冲气体来表征直线离子阱（RIT）的性能。在1至50 mtorr的压力下评估了质量分析效率，质量分辨率，隔离效率和碰撞诱导解离（CID）效率。表征了质量分辨率，分离效率和离子稳定性随压力变化的程度。另外，在各种压力下获得了最佳的共振喷射条件。在50 mtorr的操作下，质子化咖啡因（m / z 195）和Ultramark（m / z 1521）的峰宽分别为2和5 m / z单位（半峰全宽，FWHM），显示出更高的CID效率。

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