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首页> 外文期刊>Journal of mass spectrometry: JMS >Laser desorption/ionization mass spectrometric analysis of small molecules using fullerene-derivatized silica as energy-absorbing material
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Laser desorption/ionization mass spectrometric analysis of small molecules using fullerene-derivatized silica as energy-absorbing material

机译：使用富勒烯衍生化的二氧化硅作为能量吸收材料的小分子的激光解吸/电离质谱分析

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摘要

In spite of the growing acceptance of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the analysis of a wide variety of compounds, including polymers and proteins, its use in analyzing low-molecular-weight molecules (<1000 m/z) is still limited. This is mainly due to the interference of matrix molecules in the low-mass range. Here the derivatized fullerenes covalently bound to silica particles with different pore sizes are applied as thin layer for laser desorption/ionization (LDI) mass spectrometric analysis. Thus, an interference of intrinsic matrix ions can be eliminated or minimized in comparison with the state-of-the-art weak organic acid matrices. The desorption/ionization ability of the developed fullerene-silica materials depends on the applied laser power, sample preparation and pore size of the silica particles. Thus, fullerene-silica serves as an LDI support for mass spectrometric analysis of molecules (<1500 Da). The performance of the fullerene-silica is demonstrated by the mass analysis of variety of small molecules such as carbohydrates, amino acids, peptides, phospholipids and drugs.
机译：尽管越来越多地接受基质辅助激光解吸/电离飞行时间质谱分析多种化合物（包括聚合物和蛋白质）的方法，但其在分析低分子量分子（<1000 m / z）仍然有限。这主要是由于基质分子在低质量范围内的干扰。在这里，共价键合到具有不同孔径的二氧化硅颗粒的衍生富勒烯被用作薄层，用于激光解吸/电离（LDI）质谱分析。因此，与现有技术的弱有机酸基质相比，本征基质离子的干扰可以消除或最小化。所开发的富勒烯-二氧化硅材料的解吸/电离能力取决于所施加的激光功率，样品制备和二氧化硅颗粒的孔径。因此，富勒烯二氧化硅用作分子（<1500 Da）的质谱分析的LDI载体。富勒烯二氧化硅的性能通过对各种小分子（例如碳水化合物，氨基酸，肽，磷脂和药物）的质量分析得到证明。

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