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首页> 外文期刊>Journal of Functional Foods >Antihyperlipidemic effect of diosmin: A citrus flavonoid on lipid metabolism in experimental diabetic rats
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Antihyperlipidemic effect of diosmin: A citrus flavonoid on lipid metabolism in experimental diabetic rats

机译：薯di皂甙：柑橘类黄酮对实验性糖尿病大鼠脂质代谢的降血脂作用

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摘要

The present study was hypothesized to evaluated the antihyperlipidemic effect of diosmin (DS) on lipid metabolism in experimental diabetic rats. Diabetes was induced male albino Wistar rats by intraperitoneal administration of streptozotocin (STZ) (45 mg/kg b.w.) 15 min after the ip administration of nicotinamide (NA) (110 mg/kg b.w.). DS were administered to diabetic rats intragastrically at 100 mg/kg b.w. for 45 days. The levels of plasma-and tissue lipids (cholesterol, triglycerides) (TGs), free fatty acids (FFAs) and phospholipids (PLs), low density, very low-density lipoproteins (LDL and VLDL), and high-density-cholesterol (HDL-C) were measured. The activities of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, lipoprotein lipase (LPL) and lecithin cholesterol acyl transferase (LCAT) were assayed. The levels of plasma and tissue lipids decreased with significant increase in HDL-C levels. The altered activities of lipid metabolic enzymes were restored to near normal. The present findings suggest that DS can potentially ameliorate lipid abnormalities in experimental diabetes
机译：假设本研究评估了薯os皂甙（DS）对实验性糖尿病大鼠脂质代谢的抗高脂血症作用。腹膜内施用烟酰胺（NA）（110 mg / kg b.w.）15分钟后，腹膜内施用链脲佐菌素（STZ）（45 mg / kg b.w.）诱导了糖尿病。将DS以100mg / kg b.w胃内给予糖尿病大鼠胃内。持续45天。血浆和组织脂质（胆固醇，甘油三酸酯）（TGs），游离脂肪酸（FFA）和磷脂（PLs），低密度，极低密度脂蛋白（LDL和VLDL）和高密度胆固醇（测量了HDL-C）。测定了3-羟基3-甲基戊二酰辅酶A（HMG-CoA）还原酶，脂蛋白脂肪酶（LPL）和卵磷脂胆固醇酰基转移酶（LCAT）的活性。血浆和组织脂质的水平随着HDL-C水平的显着增加而降低。脂质代谢酶活性的改变恢复到接近正常。目前的发现表明，DS可以改善实验性糖尿病患者的脂质异常

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