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首页> 外文期刊>Journal of Functional Foods >Soluble dietary fibre partially hydrolysed guar gum markedly impacts on postprandial hyperglycaemia, hyperlipidaemia and incretins metabolic hormones over time in healthy and glucose intolerant subjects
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Soluble dietary fibre partially hydrolysed guar gum markedly impacts on postprandial hyperglycaemia, hyperlipidaemia and incretins metabolic hormones over time in healthy and glucose intolerant subjects

机译：膳食纤维的部分水解瓜尔胶在健康和不耐葡萄糖的受试者中会随着时间的推移显着影响餐后高血糖，高血脂和肠促胰激素

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Dietary fibre intakes have consistently been associated with reduced risk of diabetes and metabolic syndrome. We investigated in 12 healthy subjects if administration of dietary fibre partially hydrolysed guar gum (PHGG) induces beneficial impact on hyperglycaemia, hyperlipidaemia and incretins metabolic hormones. Administration of 6 g/PHGG with each meal for 12 months significantly lowered the postprandial plasma glucose (PG), reduced both the fasting and postprandial insulin (IRI) and triacylglycerol (TG) levels (p = 0.05). Low density lipoprotein (LDL) was lower, whereas high-density lipoprotein (HDL) level was significantly increased (p < 0.01). Plasma leptin, high-sensitive C-reactive protein (hs-CRP) and fasting glucagon like peptide (GLP-1) were also lowered. In fact, 3 out of 6 glucose intolerant subjects turned out to be normal glucose tolerant after only 3 months of PHGG supplementation. Therefore, this preliminary study revealed that inclusion of PHGG in diets potentially impact on metabolic health profiles by affecting circulating metabolites that are responsible for glycaemia, hyperinsulinaemia and hyperlipidaemia factors. (c) 2016 Elsevier Ltd. All rights reserved.
机译：膳食纤维的摄入一直与降低糖尿病和代谢综合征的风险有关。我们在12名健康受试者中进行了调查，如果施用膳食纤维部分水解的瓜尔豆胶（PHGG）对高血糖症，高血脂症和肠降血糖素代谢激素产生有益影响。每餐每餐服用6 g / PHGG，持续12个月，可显着降低餐后血浆葡萄糖（PG），同时降低空腹和餐后胰岛素（IRI）和三酰甘油（TG）的水平（p = 0.05）。低密度脂蛋白（LDL）较低，而高密度脂蛋白（HDL）水平则显着增加（p <0.01）。血浆瘦素，高敏C反应蛋白（hs-CRP）和空腹胰高血糖素样肽（GLP-1）也降低了。实际上，仅在补充了3个月的PHGG后，六分之三的葡萄糖耐量测试对象中就有3位是正常的葡萄糖耐量测试对象。因此，这项初步研究表明，饮食中包含PHGG可能会通过影响负责血糖，高胰岛素血症和高脂血症因素的循环代谢产物而影响代谢健康状况。 （c）2016 Elsevier Ltd.保留所有权利。

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