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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Interaction of the IP3-Ca2+ and the FGF-MAPK signaling pathways in the Xenopus laevis embryo: a qualitative approach to the mesodermal induction problem
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Interaction of the IP3-Ca2+ and the FGF-MAPK signaling pathways in the Xenopus laevis embryo: a qualitative approach to the mesodermal induction problem

机译：非洲爪蟾胚胎中的IP3-Ca2 +和FGF-MAPK信号通路的相互作用：一种定性方法来解决中胚层诱导问题

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In this work we propose that the animal-vegetal gradient spatial distribution of the IP3 receptors observed in the Xenopus embryo can effect a uniform FGF inducting input signal, allowing for different modes of transcription of the Xbra gene, producing the differentiation of the cells of the marginal zone. We analyze this hypothesis with a model for the interaction of the calcium signaling system with the MAPK cascade during the FGF mesodermal induction process, consisting of five non-linear coupled differential equations. A numerical treatment of a one- and two-cell system shows that the calcium flux between cells enhances the Raf activity levels, leading to oscillatory behavior. This qualitative result may be of consequence for the expression of the ventralizing characteristics of the FGF inducting signal. (C) 2002 Elsevier Science B.V. All rights reserved. [References: 41]
机译：在这项工作中，我们建议在非洲爪蟾胚胎中观察到的IP3受体的动物-植物梯度空间分布可以影响均匀的FGF诱导输入信号，从而允许Xbra基因转录的不同模式，从而导致非洲爪蟾细胞的分化。边缘区。我们用一个模型来分析这个假设，该模型是在FGF中胚层诱导过程中钙信号系统与MAPK级联反应的相互作用，该模型由五个非线性耦合的微分方程组成。对单细胞和两细胞系统的数值处理表明，细胞之间的钙通量会提高Raf活性水平，从而导致振荡行为。此定性结果可能是表达FGF诱导信号的腹侧化特征的结果。 （C）2002 Elsevier Science B.V.保留所有权利。 [参考：41]

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