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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Behaviour of a peptide sequence from the GB virus C/hepatitis G virus E2 protein in Langmuir monolayers: its interaction with phospholipid membrane models.
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Behaviour of a peptide sequence from the GB virus C/hepatitis G virus E2 protein in Langmuir monolayers: its interaction with phospholipid membrane models.

机译：GB丙型肝炎病毒/庚型肝炎病毒E2蛋白的肽序列在Langmuir单层中的行为：其与磷脂膜模型的相互作用。

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摘要

The GB virus C/hepatitis G virus (GBV C/HGV) is a Flaviviridae member that despite its non pathogenicity, has become of great interest given that it could inhibit the replication of the human immunodeficiency virus (HIV). Therefore, a better knowledge of the virus peptides involved in the cellular membrane fusion mechanism has become our aim. The selected peptide, named E2(347-363), corresponds to the GBV-C/HGV E2 protein and has been synthesized in order to study its interaction with in vitro membrane models. Two phospholipids, varying the charge and the unsaturations of the hydrocarbon chain have been chosen: 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dioleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (sodium salt) (DOPG). For our porpoise, we have used the Langmuir monolayer technique and Brewster angle microscopy (BAM) to gain deeper insight into the peptide/lipid interactions. The results obtained allow us to argue in favour of considering E2(347-363) a success candidate for developing further experiments in order to determine its potential role in the GBV C/HGV virus/cell membrane fusion process.
机译：GB病毒C / G肝炎病毒（GBV C / HGV）是黄病毒科成员，尽管它具有非致病性，但由于它可以抑制人类免疫缺陷病毒（HIV）的复制，因此引起了极大的兴趣。因此，更好地了解参与细胞膜融合机制的病毒肽已成为我们的目标。所选的肽名为E2（347-363），与GBV-C / HGV E2蛋白相对应，已经合成以研究其与体外膜模型的相互作用。选择了两种磷脂，它们改变了烃链的电荷和不饱和度：1,2-二棕榈酰基-sn-甘油-3-磷酸胆碱（DPPC）和1,2-二油酰基-sn-甘油-3- [phospho-rac -（1-甘油）]（钠盐）（DOPG）。对于我们的海豚，我们已使用Langmuir单层技术和Brewster角度显微镜（BAM）对肽/脂质相互作用进行了更深入的了解。获得的结果使我们可以认为E2（347-363）是成功开展进一步实验的候选人，以便确定其在GBV C / HGV病毒/细胞膜融合过程中的潜在作用。

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