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首页> 外文期刊>Journal of Agricultural Safety and Health >Childhood Cancer in Texas Counties with Moderate to Intense Agricultural Activity
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Childhood Cancer in Texas Counties with Moderate to Intense Agricultural Activity

机译：德克萨斯州中等强度农业活动县的儿童癌症

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With few established risk factors, cancer remains the second leading cause ofdeath for children in the U.S. Agricultural pesticide use is one of many suspected factors thatmay contribute to the etiology of childhood cancer. This study tests the hypothesis that birthin Texas counties with moderate to intense agricultural activity increases childhood cancerrisk. This case-control study analyzed 6,974 cases and controls ages 0 to 14, identified throughthe Texas Cancer Registry and Texas birth records, respectively. Exposure data were obtainedfrom the Census of Agriculture. Percent cropland in the county of birth and totalcounty-specific pesticide exposure incorporating the EPA's carcinogenicity classificationserved as surrogates for pesticide exposure. Cancer sites examined include: all cancers,leukemia, lymphoma, CNS tumors, and several specific subsites. Elevated, although notstatistically significant, ORs for the association between birth in counties with >=50%cropland were produced for all CNS tumors (OR = 1.3, 95% CI = 0.9-1.8), astrocytoma (OR =1.4, 95% CI = 0.8-2.2), and PNET (OR = 1.3, 95% CI = 0.7-2.5). A similar pattern was notobserved using the index of total county-specific pesticide exposure. Although imprecise,these exposure assessment methods represent novel applications of agricultural census data.Although a pattern of increased risk was observed between percent cropland and CNS tumors,this study's results do not support an association between birth in Texas counties withmoderate to intense agricultural activity and childhood cancer. Due to study limitations, suchan association should not be ruled out. Future research should incorporate individual-leveldata from various sources to increase precision and decrease misclassification in the exposureassessment.
机译：在几乎没有确定的危险因素的情况下，癌症仍然是美国儿童死亡的第二大主要原因。农业杀虫剂的使用是许多可能导致儿童癌症病因的可疑因素之一。这项研究检验了以下假设：农业活动处于中度到强烈的德克萨斯州县的出生会增加儿童患癌症的风险。这项病例对照研究分析了6,974例病例，并对照了分别通过德克萨斯州癌症登记处和德克萨斯州出生记录确定的0至14岁年龄段。暴露数据来自农业​​普查。出生县的耕地百分比和结合EPA致癌性分类的全县特定农药暴露被用作农药暴露的替代物。检查的癌症部位包括：所有癌症，白血病，淋巴瘤，中枢神经系统肿瘤和几个特定的​​亚部位。对于所有中枢神经系统肿瘤（OR = 1.3，95％CI = 0.9-1.8），星形细胞瘤（OR = 1.4，95％CI = 0.8-2.2）和PNET（OR = 1.3，95％CI = 0.7-2.5）。使用县特有农药暴露总量的指数未观察到类似的模式。尽管不精确，但这些暴露评估方法代表了农业普查数据的新颖应用。尽管在耕地百分比和中枢神经系统肿瘤之间发现了风险增加的模式，但该研究结果不支持德克萨斯州县的出生与中等强度农业活动之间的关联以及童年癌症。由于研究的局限性，不排除这种关联。未来的研究应纳入来自各种来源的个人级数据，以提高准确性并减少暴露评估中的错误分类。

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