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首页> 外文期刊>Journal of Medical Entomology >Permethrin Resistance and Target Site Insensitivity in the Mosquito Culex quinquefasciatus in Alabama
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Permethrin Resistance and Target Site Insensitivity in the Mosquito Culex quinquefasciatus in Alabama

机译：在阿拉巴马州的蚊子库蚊quinquefasciatus的苄氯菊酯抗性和目标部位不敏感。

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Insecticides are the most important component in the vector-control effort and pyrethroids such its permethrin are widely used for the indoor control of mosquitoes worldwide. However, the widespread development of resistance to pyrethroids is becoming a major problem. The current study reports an extensive survey of permethrin resistance in Alabama designed to characterize the importance of the L-to-F kdr mutation in pyrethroid resistant Culex mosquitoes. Mosquitoes were collected from 19 counties, 17 in Alabama and two from neighboring counties in Florida and Tennessee. Cidex quinquefasciatus Say from all the counties tested were found to have developed resistance to permethrin. Seventy one percent of the field population from Alabama exhibited relatively low levels of resistance, with resistance ratios ranging from 71 to 390; 11% had medium/high levels of resistance, with resistance ratios ranging from 810 to 830; and the remaining 18% had high levels of resistance, with resistance ratios ranging from 1,100 to 1,400. Most of the mosquito populations tested showed a strong correlation between their level of resistance and the frequency of L-to-F mutation expression, suggesting the importance of target site insensitivity in the development of permethrin resistance. However, four populations with elevated levels of resistance showed no L-to-F mutation in their sodium channels. Although it is possible that other mutations other than L-to-F are present in the sodium channel, resulting in permethrin resistance in these four field populations, resistance mechanisms other than target site insensitivity also must be considered.
机译：杀虫剂是媒介控制工作中最重要的组成部分，而拟除虫菊酯类的氯菊酯在全世界范围内被广泛用于室内蚊子的控制。但是，对拟除虫菊酯的抗性的广泛发展正成为一个主要问题。本研究报道了在阿拉巴马州对苄氯菊酯抗药性的广泛调查，旨在表征拟除虫菊酯抗药性库蚊的L-to-f kdr突变的重要性。蚊子采集自19个县，阿拉巴马州的17个县和两个佛罗里达州和田纳西州的相邻县。来自所有测试县的Cidex quinquefasciatus说都被发现对氯菊酯有抗药性。来自阿拉巴马州的71％的野外种群表现出相对较低的抗性水平，抗性比在71至390之间。 11％的人具有中/高水平的电阻，电阻比为810至830;其余18％的电阻水平较高，电阻比在1100至1400之间。所测试的大多数蚊子种群的抵抗力水平与L-to-F突变表达的频率之间都具有很强的相关性，这表明在苄氯菊酯抗药性发展过程中靶位点不敏感的重要性。但是，四个耐药水平较高的人群在其钠通道中未显示L-to-F突变。尽管钠通道中可能存在L-to-F以外的其他突变，导致这4个田间种群对氯菊酯有抗药性，但还必须考虑靶位点不敏感性以外的抗药性机制。

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