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首页> 外文期刊>Journal of Medical Entomology >An Insight Into the Sialotranscriptome of Triatoma rubida (Hemiptera: Heteroptera)
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An Insight Into the Sialotranscriptome of Triatoma rubida (Hemiptera: Heteroptera)

机译：深入了解红藻鞭毛虫的唾液转录组（半翅目：异翅目）

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摘要

The kissing bug Triatoma rubida (Uhler, 1894) is found in southwestern United States and parts of Mexico where it is found infected with Trypanosoma cruzi, invades human dwellings and causes allergies from their bites. Although the protein salivary composition of several triatomine species is known, not a single salivary protein sequence is known from T. rubida. Furthermore, the salivary diversity of related hematophagous arthropods is very large probably because of the immune pressure from their hosts. Here we report the sialotranscriptome analysis of T. rubida based on the assembly of 1,820 high-quality expressed sequence tags, 51% of which code for putative secreted peptides, including lipocalins, members of the antigen five family, apyrase, hemolysin, and trialysin families. Interestingly, T. rubida lipocalins are at best 40% identical in primary sequence to those of T. protracta, a kissing bug that overlaps its range with T. rubida, indicating the diversity of the salivary lipocalins among species of the same hematophagous genus. We additionally found several expressed sequence tags coding for proteins of clear Trypanosoma spp. origin. This work contributes to the future development of markers of human and pet exposure to T. rubida and to the possible development of desensitization therapies. Supp. Data 1 and 2(online only) of the transcriptome and deducted protein sequences can be obtained from http://exon.niaid.nih.gov/transcriptome/Trubida/Triru-S1-web.xlsx and http://exon.niaid.nih.gov/transcriptome/Trubida/Triru-S2-web.xlsx.
机译：接吻小虫Triatoma rubida（乌勒，1894年）在美国西南部和墨西哥的部分地区被发现，在那里被克鲁氏锥虫感染，侵袭人类的住所并引起其叮咬过敏。尽管已知几种三atomine种类的蛋白质唾液组成，但从风铃木中不知道单个唾液蛋白质序列。此外，相关的食血节肢动物的唾液多样性非常大，可能是由于其宿主的免疫压力所致。在这里，我们基于1,820个高质量表达序列标签的组装情况报告了风铃草的唾液酸转录组分析，其中51％编码假定的分泌肽，包括脂蛋白，五抗原家族成员，腺苷三磷酸腺苷酶，溶血素和三联胞菌素家族。有趣的是，红斑紫花苜蓿脂蛋白在一级序列上与延性紫薇（T. protracta）的同源性最多为40％，后者是一个亲吻虫，与红斑紫菜重叠，表明相同嗜血属物种之间唾液脂白蛋白的多样性。我们还发现了几个表达的序列标签，它们编码透明锥虫的蛋白。起源。这项工作为人类和宠物暴露于红斑病菌的标记物的未来发展以及脱敏疗法的可能发展做出了贡献。补给转录组和扣除的蛋白质序列的数据1和2（仅在线）可从http://exon.niaid.nih.gov/transcriptome/Trubida/Triru-S1-web.xlsx和http：//exon.niaid获得.nih.gov / transcriptome / Trubida / Triru-S2-web.xlsx。

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