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首页> 外文期刊>Journal of Medical Entomology >Laboratory selection of resistance to spinosad in Culex quinquefasciatus (Diptera: Culicidae).
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Laboratory selection of resistance to spinosad in Culex quinquefasciatus (Diptera: Culicidae).

机译：实验室对库蚊（Culex quinquefasciatus）（双翅目：库蚊科）中对多杀菌素的抗性选择。

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摘要

A southern house mosquito Culex quinquefasciatus Say colony was established from surviving late instars and pupae from a semifield evaluation on Natular XRG (a granular formulation containing 2.5% spinosad). The initial lethal levels of Natular XRG against this colony were determined in the laboratory for the first-generation progeny (designated as F1). Selection pressure was applied at LC70-90 levels to 10,000-15,000 late third- and early fourth-instar larvae of each generation with Natular XRG. Susceptibility changes in response to selection were determined every other generation, where a gradual and steady decline in susceptibility occurred from generation F1 to F35, followed by significant decline from generations F37 to F45. For reference purposes, susceptibility of freshly collected wild populations as well as a laboratory colony of the same species was also determined concurrently, which fluctuated within a slightly wider range for the wild populations and a tighter range for the laboratory colony. By comparing with wild populations and laboratory reference colony, tolerance to spinosad was observed from generations up to F9 in the selected population. Resistance levels increased gradually from generation F11 to F35, and elevated significantly from generations F37 to F45, when resistance ratios reached 1,415.3- to 2,229.9-fold at LC50 and 9,613.1- to 17,062.6-fold at LC90. Possible mechanisms of resistance development to spinosad were discussed.
机译：通过在Natular XRG（一种含有2.5％的spinosad的颗粒制剂）的半田评估中，从存活的晚龄幼虫和established中建立了南部的家蚊库克斯库克斯奎克西塔斯说栖息地。在实验室中确定了第一代后代（称为F 1 ）的原始XRG致死率。用纳塔尔XRG将选择压力按LC 70-90 的水平施加至10,000-15,000的第三代和四龄初期幼虫。每隔两代就确定对选择的敏感性变化，从F 1 代到F 35 代的敏感性逐渐下降，随后F代显着下降。 37 到F 45 。出于参考目的，同时确定了新鲜采集的野生种群以及同一物种的实验室菌落的敏感性，其在野生种群的范围内波动较大，而在实验室菌落的范围内波动较小。通过与野生种群和实验室参考菌落进行比较，在选定的种群中观察到对多杀菌素的耐受性高达F 9 。抗性水平从F 11 世代逐渐增加到F 35 ，从F 37 世代到F 45 世代显着提高，当LC 50 的电阻比达到1,415.3-至2,229.9-倍，LC 90 的电阻比达到9,613.1-至17,062.6-倍时。讨论了对多杀菌素抗药性的可能机制。

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