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首页> 外文期刊>Journal of Medical Genetics >Risk of thyroid cancer in first-degree relatives of patients with non-medullary thyroid cancer by histology type and age at diagnosis: A joint study from five nordic countries
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Risk of thyroid cancer in first-degree relatives of patients with non-medullary thyroid cancer by histology type and age at diagnosis: A joint study from five nordic countries

机译：按组织学类型和年龄分类的非髓样甲状腺癌患者一级亲属的甲状腺癌风险：来自五个北欧国家的联合研究

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Background: We aimed to estimate lifetime cumulative risk of thyroid cancer (CRTC) in first-degree relatives of patients with non-medullary thyroid cancers (NMTC), including papillary (PTC)/follicular/oxyphilic/anaplastic thyroid carcinoma, by histology and age at diagnosis in patients and their relatives. Design: A population-based cohort of 63 495 firstdegree relatives of 11 206 NMTC patients diagnosed in 1955-2009 in Nordic countries was followed for cancer incidence. Standardised incidence ratios (SIRs) were calculated using histology-specific, age-specific, sexspecific, period-specific and country-specific incidence rates as reference. Results: The 0-84-year CRTC in female relatives of a patient with PTC was 2%, representing a threefold increase over the general population risk (SIR=2.9, 95% CI 2.4 to 3.4; Men: CRTC=1%, SIR=2.5, 95% CI 1.9 to 3.3). When there were ≥2 PTC patients diagnosed at age <60 years in a family, CRTC for female relatives was 10% (male 24%). Twins had a 23-fold increased risk of concordant PTC. Family history of follicular/oxyphilic/ anaplastic carcinoma increased CRTC in relatives to about 1-2%. Although no familial case of concordant oxyphilic/anaplastic carcinoma was found, familial risks of discordant histology types of NMTC were interchangeably high for most of the types, for example, higher risk of PTC when a first-degree relative had follicular (SIR=3.0, 95%CI 1.7 to 4.9) or anaplastic (SIR=3.6, 95% CI 1.2 to 8.4) carcinoma. The earlier a patient was diagnosed with PTC in a family, the higher was the SIR in his/her younger relatives. There was a tendency towards concordant age at diagnosis of thyroid cancer among relatives of PTC patients. Conclusions: This study provides clinically relevant risk estimates for family members of NMTC patients.
机译：背景：我们旨在通过组织学和年龄来评估非髓样甲状腺癌（NMTC）（包括乳头状癌（PTC）/滤泡/嗜氧/间变性甲状腺癌）一级亲属的甲状腺癌（CRTC）终生累积风险。患者及其亲属的诊断。设计：追踪了一组在1955-2009年间在北欧国家诊断为11 206例NMTC患者的63 495名一级亲属的队列研究。使用特定于组织学，特定年龄，性别，特定时期和特定国家的发病率作为参考，计算标准化的发病率（SIR）。结果：PTC患者女性亲属的0-84年CRTC为2％，比一般人群风险高出三倍（SIR = 2.9，95％CI 2.4至3.4;男性：CRTC = 1％，SIR = 2.5，95％CI 1.9至3.3）。当一个家庭中有≥2名年龄在60岁以下的PTC患者被诊断时，女性亲属的CRTC为10％（男性24％）。双胞胎的PTC患病风险增加了23倍。滤泡性/嗜氧性/间变性癌的家族史使亲属的CRTC升高约1-2％。尽管未发现家族性嗜氧性/间变性癌的病例，但对于大多数类型，NMTC组织学类型不一致的家族性风险可互换地较高，例如，一级亲属有卵泡时，PTC的风险较高（SIR = 3.0， 95％CI 1.7至4.9）或间变性癌（SIR = 3.6，95％CI 1.2至8.4）。一个家庭中越早被诊断出患有PTC的患者，他/她的年轻亲戚中的SIR越高。 PTC患者的亲属在诊断甲状腺癌时趋向于一致的年龄。结论：该研究为NMTC患者的家庭成员提供了临床相关的风险估计。

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