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首页> 外文期刊>Journal of Macromolecular Science. Pure and Applied Chemistry >Hydrophobically modified poly(allylamine) hydrogels containing internal quaternary ammonium groups as cholesterol lowering agents: Synthesis, characterization, and biological studies
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Hydrophobically modified poly(allylamine) hydrogels containing internal quaternary ammonium groups as cholesterol lowering agents: Synthesis, characterization, and biological studies

机译：含有内部季铵基团作为胆固醇降低剂的疏水改性聚烯丙胺水凝胶：合成，表征和生物学研究

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摘要

Syntheses and physico-chemical characterization of a series of amphiphilic cationic hydrogels bearing pendant quaternary ammonium groups based on poly(allylamine) backbone are reported. These amphiphilic hydrogels were prepared by crosslinking soluble poly(allylamine) with epichlorohydrin followed by alkylation of the resulting gel with different functional alkyl chlorides bearing quaternary ammonium groups. Equilibrium swelling characteristics of these amphiphilic hydrogels were determined under a variety of solvent conditions. The roles of different parameters such as degree of crosslinking, degree of alkylation, and nature of alkylating agents on the swelling properties of these hydrogels were investigated. As part of a continuing structure-activity relationship study for the discovery of systemically non-absorbed cholesterol lowering agents, these amphiphilic hydrogels were also evaluated for their bile acid sequestration properties. Preliminary in vivo studies suggest these cationic hydrogels are potent bile acid sequestrants.
机译：报道了一系列基于聚（烯丙胺）骨架的季铵盐侧基的两亲阳离子水凝胶的合成和理化性质。这些两亲水凝胶是通过将可溶性聚烯丙胺与环氧氯丙烷交联，然后将所得凝胶用带有季铵基团的不同官能烷基氯烷基化而制得的。这些两亲水凝胶的平衡溶胀特性是在各种溶剂条件下测定的。研究了交联度，烷基化度和烷基化剂性质等参数对这些水凝胶溶胀性能的影响。作为发现全身性非吸收性胆固醇降低剂的持续结构-活性关系研究的一部分，还对这些两亲性水凝胶的胆汁酸螯合特性进行了评估。体内初步研究表明，这些阳离子水凝胶是有效的胆汁酸螯合剂。

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