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首页> 外文期刊>Journal of microbiology and biotechnology >Wewakamide a and guineamide g, cyclic depsipeptides from the marine cyanobacteria lyngbya semiplena and lyngbya majuscula
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Wewakamide a and guineamide g, cyclic depsipeptides from the marine cyanobacteria lyngbya semiplena and lyngbya majuscula

机译：Wewakamide a和guineamide g，来自海洋蓝藻lyngbya semiplena和lyngbya majuscula的环状二肽

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摘要

Two new cyclic depsipeptides wewakamide A (1) and guineamide G (2) have been isolated from the marine cyanobacterium Lyngbya semiplena and Lyngbya majuscula, respectively, collected from Papua New Guinea. The amino and hydroxy acid partial structures of wewakamide A and guineamide G were elucidated through extensive spectroscopic techniques, including HR-FABMS, 1D 1H and ~(13)C NMR, as well as 2D COSY, HSQC, HSQCTOCSY, and HMBC spectra. The sequence of the residues of wewakamide A was determined through a combination of ESI-MS/MS, HMBC, and ROESY. Wewakamide A possesses a β-amino acid, 3-amino-2-methylbutanoic acid (Maba) residue, which has only been previously identified in two natural products, guineamide B (3) and dolastatin D (4). Although both new compounds (1,2) showed potent brine shrimp toxicity, only guineamide G displayed significant cytotoxicity to a mouse neuroblastoma cell line with LC _(50) values of 2.7 μM.
机译：已分别从巴布亚新几内亚收集的海洋蓝细菌半生Lyngbya semiplena和Lyngbya majuscula中分离出两个新的环状二肽肽wewakamide A（1）和几内酰胺G（2）。通过广泛的光谱技术，包括HR-FABMS，1D 1H和〜（13）C NMR以及2D COSY，HSQC，HSQCTOCSY和HMBC光谱，阐明了wewakamide A和几内酰胺G的氨基和羟基酸部分结构。通过结合ESI-MS / MS，HMBC和ROESY确定wewakamide A的残基序列。 Wewakamide A拥有一个β-氨基酸，3-氨基-2-甲基丁酸（Maba）残基，该残基先前仅在两种天然产物中被确认，即几内酰胺B（3）和dolastatin D（4）。尽管两种新化合物（1,2）均显示出强力的盐水虾毒性，但只有Guineamide G对小鼠神经母细胞瘤细胞系的LC_（50）值为2.7μM表现出明显的细胞毒性。

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