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首页> 外文期刊>Journal of microbiology and biotechnology >Identification of the Fur-binding site in regulatory region of the vulnibactin-receptor gene in Vibrio vulnificus
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Identification of the Fur-binding site in regulatory region of the vulnibactin-receptor gene in Vibrio vulnificus

机译：创伤弧菌中外泌素受体基因调控区Fur结合位点的鉴定

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摘要

The Vibrio vulnificus vuuA gene, of which expression is repressed by a complex of iron and ferric uptake regulator (Fur), was characterized to localize the Fur-binding site in its upstream regulatory region. In silico analysis suggested the presence of two possible Fur-binding sites; one is a classical Fur-box and the other is a previously reported distinct Fur-binding site. Site-directed mutagenesis and DNase I protection assays revealed the binding site for the iron-Fur complex, which includes an extended inverted repeat containing a homologous sequence to the classical Fur-box.
机译：创伤弧菌vuuA基因的表达受铁和铁摄取调节剂（Fur）的复合物抑制，其特征在于将Fur结合位点定位在其上游调节区域。在计算机分析中提示存在两个可能的Fur结合位点。一个是经典的毛皮盒，另一个是先前报道的独特的毛皮结合位点。定点诱变和DNase I保护测定揭示了铁-Fur复合物的结合位点，其中包括一个延伸的反向重复序列，该序列包含与经典Fur-box同源的序列。

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