Giant DNA molecules exhibit on/off switching of transcriptional activity through conformational transition

Tsumoto K.; Luckel F.; Yoshikawa K.

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Giant DNA molecules exhibit on/off switching of transcriptional activity through conformational transition

机译：巨型DNA分子通过构象转变显示转录活性的开/关切换

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We found that the transcriptional activity of large DNAs (40 kbp) can be completely inhibited by adding condensing agents, spermine and poly(ethylene glycol), whereas under the same conditions short fragments (140 bp) still show active transcription. Fluorescence microscopic observations of large DNAs revealed clear correlation between the higher-order structure of templates and their transcriptional activity. The steep decrease in transcriptional activity leading to complete inhibition, or on/off switching, is interpreted in terms of conformational transition of the ensemble of DNA molecules. (C) 2003 Elsevier Science B.V. All rights reserved. [References: 32]

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《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |2003年第1期|共7页
作者
Tsumoto K.; Luckel F.; Yoshikawa K.;
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正文语种 eng
中图分类生物化学;
关键词
Transcriptional activity; Dna condensation; Higher-order structure of dna; Spermine; Poly(ethylene glycol); Fluorescence microscopy; Higher-order structure; In-vitro; Multivalent cations; Phase-transition; Duplex dna; Condensation; Polyamines; Spermidine; Chromatin; Vivo;

机译：转录活性;Dna缩合;dna的高级结构;精胺;聚乙二醇;荧光显微镜;高级结构;体外;多价阳离子;相转变;双链dna;缩合;多胺;亚精胺;染色质;Vivo;

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1. Giant DNA molecules exhibit on/off switching of transcriptional activity through conformational transition [J] . Tsumoto K., Luckel F., Yoshikawa K. Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2003,第1期

机译：巨型DNA分子通过构象转变显示转录活性的开/关切换
2. ON-OFF Switching of Transcriptional Activity of Large DNA through a Conformational Transition in Cooperation with Phospholipid Membrane [J] . Akihiko Tsuji, Kenichi Yoshikawa Journal of the American Chemical Society . 2010,第35期

机译：大构型的转录活性与磷脂膜协同构象过渡的ON-OFF切换。
3. ON−OFF Switching of Transcriptional Activity of Large DNA through a Conformational Transition in Cooperation with Phospholipid Membrane [J] . Akihiko Tsuji Journal of the American Chemical Society . 2010,第35期

机译：通过构象过渡与磷脂膜的合作，大DNA转录活性的ON-OFF切换。
4. Microflow system and transportation of DNA molecule by dielectrophoretic force utilizing the conformational transition in the higher order structure of DNA molecule [C] . Morishima, K., Fukuda, . 1997

机译：微流系统和利用介电泳力利用DNA分子高阶结构中的构象转变转运DNA分子
5. Probing single -stranded DNA structure and conformational transitions with single-molecule fluorescence spectroscopy [D] . Kurtz, Andrea H. 2008

机译：用单分子荧光光谱仪探测单链DNA结构和构象转变
6. ON−OFF Switching of Transcriptional Activity of Large DNA through a Conformational Transition in Cooperation with Phospholipid Membrane [O] . Akihiko Tsuji, *, Kenichi Yoshikawa, -1

机译：通过构象过渡与磷脂膜的合作大DNA转录活性的ON-OFF切换。
7. All-or-none switching of transcriptional activity on single DNA molecules caused by a discrete conformational transition [O] . Yamada A, Kubo K, Nakai T, 2005

机译：由离散的构象转变导致的单个DNA分子上转录活性的全或无转换

Giant DNA molecules exhibit on/off switching of transcriptional activity through conformational transition

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