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首页> 外文期刊>Journal of Avian Medicine and Surgery >Pharmacokinetics of Compounded Intravenous and Oral Gabapentin in Hispaniolan Amazon Parrots (Amazona ventralis)
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Pharmacokinetics of Compounded Intravenous and Oral Gabapentin in Hispaniolan Amazon Parrots (Amazona ventralis)

机译：复合静脉和口服加巴喷丁在西班牙裔亚马逊鹦鹉（Amazona ventralis）中的药代动力学

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摘要

Neuropathic pain is a manifestation of chronic pain that arises with damage to the somatosensory system. Pharmacologic treatment recommendations for alleviation of neuropathic pain are often multimodal, and the few reports communicating treatment of suspected neuropathic pain in avian patients describe the use of gabapentin as part of the therapeutic regimen. To determine the pharmacokinetics of gabapentin in Hispaniolan Amazon parrots (Amazona ventralis), compounded gabapentin suspensions were administered at 30 mg/kg IV to 2 birds, 10 mg/kg PO to 3 birds, and 30 mg/kg PO to 3 birds. Blood samples were collected immediately before and at 9 different time points after drug administration. Plasma samples were analyzed for gabapentin concentration, and pharmacokinetic parameters were calculated with both a nonlinear mixed-effect approach and a noncompartmental analysis. The best compartmental, oral model was used to simulate the concentration-time profiles resulting from different dosing scenarios. Mild sedation was observed in both study birds after intravenous injection. Computer simulation of different dosing scenarios with the mean parameter estimates showed that 15 mg/kg every 8 hours would be a starting point for oral dosing in Hispaniolan Amazon parrots based on effective plasma concentrations reported for human patients; however, additional studies need to be performed to establish a therapeutic dose.
机译：神经性疼痛是一种慢性疼痛的表现，是由于身体感觉系统受损而引起的。减轻神经性疼痛的药物治疗建议通常是多式联运的，很少有报道传达禽类患者可疑神经性疼痛的治疗的报告描述了加巴喷丁作为治疗方案的一部分。为了确定加巴喷丁在西班牙裔亚马逊鹦鹉（Amazona ventralis）中的药代动力学，将复合加巴喷丁混悬液以30 mg / kg的IV剂量给药至2只禽，以10 mg / kg的PO给药至3只禽，以30 mg / kg的PO给药至3只禽。在给药前和给药后9个不同时间点采集血样。分析血浆样品中加巴喷丁的浓度，并用非线性混合效应方法和非房室分析法计算药代动力学参数。最佳的隔室口服模型用于模拟不同剂量情况下的浓度-时间曲线。静脉注射后，两只研究鸟类均观察到轻度镇静作用。根据平均剂量估计值对不同剂量方案的计算机模拟显示，每8小时15 mg / kg将是基于人类患者报告的有效血浆浓度口服口服西班牙裔亚马逊鹦鹉的起点;但是，还需要进行其他研究来确定治疗剂量。

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