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首页> 外文期刊>Journal of magnetic resonance >Nearly 10(6)-fold enhancements in intermolecular H-1 double-quantum NMR experiments by nuclear hyperpolarization
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Nearly 10(6)-fold enhancements in intermolecular H-1 double-quantum NMR experiments by nuclear hyperpolarization

机译：分子间H-1双量子NMR实验通过核超极化将近10（6）倍增强

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Intermolecular Multiple-Quantum Coherences (iMQCs) can yield interesting NMR information of high potential usefulness in spectroscopy and imaging - provided their associated sensitivity limitations can be overcome. A recent study demonstrated that ex situ dynamic nuclear polarization (DNP) could assist in overcoming sensitivity problems for iMQC-based experiments on C-13 nuclei. In the present work we show that a similar approach is possible when targeting the protons of a hyperpolarized solvent. It was found that although the DNP procedure enhances single-quantum H-1 signals by about 600, which is significantly less than in optimized low-gamma liquid-state counterparts, the non-linear dependence of iMQC-derived signals on polarization can yield very large enhancements approaching 10(6), Cleary no practical amount of data averaging can match this kind of sensitivity gains. The fact that DNP endows iMQC-based H-1 NMR spectra with a sensitivity that amply exceeds that of their thermally polarized single-quantum counterpart, is confirmed in a number of simple single-scan 2D imaging experiments.
机译：分子间多量子相干（iMQC）可以产生有趣的NMR信息，在光谱学和成像中具有很高的潜在用途-只要可以克服它们的相关灵敏度限制。最近的一项研究表明，异位动态核极化（DNP）可以帮助克服基于iMQC的C-13核实验的敏感性问题。在目前的工作中，我们表明，当靶向超极化溶剂的质子时，类似的方法也是可行的。已发现，尽管DNP程序将单量子H-1信号增强了约600，这明显低于优化的低伽玛液态对应物，但iMQC衍生信号对偏振的非线性依赖性会产生非常大的变化。大的增强将近10（6），显然没有任何实际的数据平均可以匹配这种灵敏度增益。在许多简单的单扫描2D成像实验中都证实了DNP赋予基于iMQC的H-1 NMR光谱的灵敏度远远超过其热极化单量子对应物的灵敏度这一事实。

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