On the Importance of Exchangeable NH Protons in Creatine for the Magnetic Coupling of Creatine Methyl Protons in Skeletal Muscle

M. J. Kruiskamp; K. Nicolay

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On the Importance of Exchangeable NH Protons in Creatine for the Magnetic Coupling of Creatine Methyl Protons in Skeletal Muscle

机译：肌酸中可交换NH质子对骨骼肌中肌酸甲酯质子磁耦合的重要性

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The methyl protons of creatine in skeletal muscle exhibit a strong off-resonance magnetization transfer effect. The mechanism of this process is unknown. We previously hypothesized that the exchange-able amide/amino protons of creating might be involved. To test this the characteristics of the creatine magnetization transfer effect were investigated in excised rat hindleg skeletal muscle that was equilibrated in either H_2O or D_2O solutions containing creatine. The efficiency of off-resonance magnetization transfer to the protons of mobile creatine in excised muscle was similar to that previously reported in intact muscle in vivo. Equilibrating the isolated muscle in D_2O solution had no effect on the magnetic coupling to the immobile protons. It is concluded that exchangeable protons play a negligible role in the magnetic coupling of creatine methyl protons in muscle.

机译：骨骼肌中肌酸的甲基质子表现出很强的非共振磁化转移效应。此过程的机制尚不清楚。我们先前假设，可能涉及创造的可交换酰胺/氨基质子。为了检验这一点，研究了在含有肌酸的H_2O或D_2O溶液中平衡的大鼠后肢骨骼肌中肌酸磁化传递效应的特性。在切除的肌肉中，非共振磁化转移到移动性肌酸的质子的效率类似于先前在体内完整肌肉中报道的效率。在D_2O溶液中平衡孤立的肌肉对与固定质子的磁耦合没有影响。结论是，可交换质子在肌肉中肌酸甲基质子的磁耦合中起着微不足道的作用。

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《Journal of magnetic resonance》 |2001年第1期|共5页
作者
M. J. Kruiskamp; K. Nicolay;
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正文语种 eng
中图分类电磁学、电动力学;磁学;
关键词
creatine; magnetization transfer; deuterium; exchange; muscle;

机译：肌酸;磁化转移;氘;交换;肌肉;

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1. On the Importance of Exchangeable NH Protons in Creatine for the Magnetic Coupling of Creatine Methyl Protons in Skeletal Muscle [J] . M. J. Kruiskamp, K. Nicolay Journal of magnetic resonance . 2001,第1期

机译：肌酸中可交换NH质子对骨骼肌中肌酸甲酯质子磁耦合的重要性
2. On the Importance of Exchangeable NH Protons in Creatine for the Magnetic Coupling of Creatine Methyl Protons in Skeletal Muscle [J] . M. J. Kruiskamp, K. Nicolay JOM . 2001,第1期

机译：肌酸中可交换NH质子对骨骼肌中肌酸甲酯质子磁耦合的重要性
3. Magnetic coupling between water and creatine protons in human brain and skeletal muscle, as measured using inversion transfer (1)H-MRS. [J] . Kruiskamp MJ, de-Graaf RA, van-der-Grond J, NMR in biomedicine . 2001,第1期

机译：人脑和骨骼肌中水与肌酸质子之间的磁耦合，使用反转转移（1）H-MRS测量。
4. H/D exchange of skeletal protons to develop targeted synthesis of humic-like substances [C] . A. Zherebker, Y. Kostyukevich, A.S. Kononikhin The Meeting of the International Humic Substances Society . 2015

机译：H / D骨骼质子的交换，开发有针对性的腐殖质物质的合成
5. Interactions of smooth muscle and skeletal muscle pyruvate kinases with creatine kinase. [D] . Sears, Patrick Robert. 2000

机译：平滑肌和骨骼肌丙酮酸激酶与肌酸激酶的相互作用。
6. Decreased Taurine and Creatine in the Thalamus May Relate to Behavioral Impairments in Ethanol-Fed Mice: A Pilot Study of Proton Magnetic Resonance Spectroscopy [O] . Su Xu, Wenjun Zhu, Yamin Wan, 2018

机译：丘脑中牛磺酸和肌酸的减少可能与乙醇喂养小鼠的行为障碍有关：质子磁共振波谱的初步研究
7. Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle. [O] . Guerrero Karen, Wuyam Bernard, Mezin Paulette, 2005

机译：在肺移植骨骼肌中进行运动训练后，腺嘌呤核苷酸转位酶和线粒体肌酸激酶的功能偶联增强。

On the Importance of Exchangeable NH Protons in Creatine for the Magnetic Coupling of Creatine Methyl Protons in Skeletal Muscle

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