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首页> 外文期刊>Journal of magnetic resonance >In Vivo ~(31)P Echo-Planar Spectroscopic Imaging of Human Calf Muscle
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In Vivo ~(31)P Echo-Planar Spectroscopic Imaging of Human Calf Muscle

机译：小腿肌肉的〜（31）P超声平面体内成像

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摘要

Localized phosphorus-31 NMR spectra of human calf muscle in vivo were obtained by means of echo-planar spectroscopic imaging (EPSI) with a 1.5-T whole-body scanner. The technique permits the measurement f two-dimensional ~(31)P SI data at a minimum acquisition time of 2.4 s (8 * 8 voxels, TR = 300 ms). With 9.4 min measurement time (TR = 1100 ms, 64 averages) and 25 * 25 * 40 mm spatial resolution in vivo the ~(31)P NMR signal-to-noise ratio (S/N) of the phosphocreatine (PCr) resonance was about 45; the multiplets of nucleoside 5'-triphosphates were resolved. Spectral quality permits quantitative assessment of the PCr signal in a measurement tie that is shorter by a factor of 2 or more than the minimum measurement time feasible with chemical-shift imaging. In a functional EPSI study with a time resolution of 20.5 s on the calf muscle of volunteers, spectra showed a 40% decrease of the PCr signal intensity (at rest: S/N approx= 12) upon exertion of the muscle.
机译：通过1.5T全身扫描仪的回波平面光谱成像（EPSI）获得了人体小腿肌肉的局部磷31 NMR光谱。该技术允许在最小采集时间为2.4 s（8 * 8体素，TR = 300 ms）的情况下测量二维〜（31）P SI数据。测量时间为9.4分钟（TR = 1100毫秒，平均64次），体内空间分辨率为25 * 25 * 40 mm，磷酸肌酸（PCr）共振的〜（31）P NMR信噪比（S / N）大约是45岁;解决了5'-三磷酸核苷的多重峰。光谱质量允许对测量领带中的PCr信号进行定量评估，该测量领带比化学位移成像可行的最短测量时间短2倍或更多倍。在一项功能性EPSI研究中，志愿者在小腿肌肉上的时间分辨率为20.5 s，光谱显示，在施加肌肉时，PCr信号强度降低40％（静止时，S / N约= 12）。

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