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首页> 外文期刊>Journal of magnetic resonance >Signal Dynamics in Magnetic Resonance Imaging of the Lung with Hyperpolarized Noble Gases
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Signal Dynamics in Magnetic Resonance Imaging of the Lung with Hyperpolarized Noble Gases

机译：超极化稀有气体在肺部磁共振成像中的信号动力学

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The nonequilibrium bulk magnetic moment of hyperpolarized (HP) noble gases generated by optical pumping has unique characteristics. Based on the Bloch equations, a model was developed describing the signal dynamics of HP gases used in magnetic resonance imaging (MRI) of the lung special consideration to the breathing cycle. Experimental verification included extensive investigations with HP ~3He and ~(129)Xe during both inspiration and held breath in live guinea pigs. Radial acquisition was used to investigate the view variations with a temporal resolution of 5 ms. Agreement between theoretical predictions and in vivo results was excellent. Additionally, information about effects from noble gas diffusion and spin-lattice relaxation was obtained. In vivo results for T_1 were 28.8 ± 1.8 s for ~3He and 31.3 ± 1.8 s for ~(129)Xe. Comparison with in vitro data indicated that relaxation in the pulmonary gas space is dominated by dipolar coupling with molecular oxygen. The results provide a quantitative basis for optimizing pulse sequence design in HP gas MRI of the lung.
机译：光泵浦产生的超极化（HP）稀有气体的非平衡体磁矩具有独特的特性。基于Bloch方程，开发了一个模型，该模型描述了在肺部磁共振成像（MRI）中特别考虑到呼吸周期的高压气体的信号动力学。实验验证包括在活的豚鼠吸气和屏气期间使用HP〜3He和〜（129）Xe进行广泛的研究。径向采集用于研究时间分辨率为5 ms的视图变化。理论预测与体内结果之间的一致性非常好。另外，获得关于稀有气体扩散和自旋晶格弛豫的影响的信息。 T_1的体内结果对于3He约为28.8±1.8 s，对于（（129）Xe）约为31.3±1.8 s。与体外数据的比较表明，肺气体空间的松弛主要是与分子氧偶极偶联。该结果为优化肺部高压气体MRI中的脉冲序列设计提供了定量依据。

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