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Xenon-based molecular sensors in lipid suspensions

机译：脂质悬浮液中基于氙气的分子传感器

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摘要

There have been many proposals to use xenon-based molecular sensors in biological settings. Fundamental to understanding the properties of these sensors in vivo is characterizing their behavior in lipid environments. We report the investigation of xenon-based molecular sensors in suspensions of lipid vesicles with a size comparable to cells. We detail spectroscopic properties of sensors associated with lipid vesicles as well as those in equilibrium in the surrounding solution. We characterize the dependence of the spectral parameters on temperature, relevant for studies at physiological temperatures. We also demonstrate the ability to perform selective saturation transfer (Hyper-CEST) between sensor, both lipid bound and unbound, and the bulk solution. Lastly, we demonstrate the applicability of saturation transfer in the heterogeneous medium as an imaging modality.
机译：已经有许多建议在生物环境中使用基于氙的分子传感器。理解这些传感器在体内的特性的基础是表征其在脂质环境中的行为。我们报道了基于氙气的分子传感器在脂质囊泡的悬浮液中的研究，其大小与细胞相当。我们详细介绍了与脂质囊泡以及周围溶液平衡状态下的传感器相关的光谱特性。我们表征了光谱参数对温度的依赖性，这与在生理温度下的研究有关。我们还展示了在脂质结合和未结合的传感器与整体溶液之间执行选择性饱和转移（Hyper-CEST）的能力。最后，我们证明了在异质介质中饱和转移作为一种成像方式的适用性。

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