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首页> 外文期刊>Journal of magnetic resonance imaging: JMRI >Three-dimensional (3D) visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: optimization of a 3D-real inversion-recovery turbo spin-echo (TSE) sequence and application of a 32-channel head coil at 3T.
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Three-dimensional (3D) visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: optimization of a 3D-real inversion-recovery turbo spin-echo (TSE) sequence and application of a 32-channel head coil at 3T.

机译：鼓室内注射Gd-DTPA后的内淋巴积液的三维（3D）可视化：优化3D实数反转恢复涡轮自旋回波（TSE）序列并在3T应用32通道头线圈。

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PURPOSE: To enable volume visualization of endolymphatic hydrops of Meniere's disease via a volume rendering (VR) technique, a three-dimensional (3D) inversion-recovery (IR) sequence with real reconstruction (3D-real IR) sequence after intratympanic injection of Gd-DTPA was optimized for higher spatial resolution using a 32-channel head coil at 3T. MATERIALS AND METHODS: Pulse sequence parameters were optimized using a diluted Gd-DTPA phantom. Then, 11 patients who had been clinically diagnosed with Meniere's disease and a patient with sudden hearing loss were scanned. Images were processed using commercially available 3D-VR software. 3D-real IR data was processed to produce endolymph and perilymph fluid volume images in different colors. 3D-CISS data was processed to generate total fluid volume images. RESULTS: While maintaining a comparable signal-to-noise ratio (SNR) and scan time, the voxel volume could be reduced from 0.4 x 0.4 x 2 mm(3) with a 12-channel coil to 0.4 x 0.4 x 0.8 mm(3) with a 32-channel coil. A newly-optimized protocol allowed the smooth, three-dimensional visualization of endolymphatic hydrops in all patients with Meniere's disease. CONCLUSION: Volumetrically separate visualization of endo-/perilymphatic space is now feasible in patients with Meniere's disease using an optimized 3D-real IR sequence, a 32-channel head coil, at 3T, after intratympanic administration of Gd-DTPA. This will aid the understanding of the pathophysiology of Meniere's disease.
机译：目的：为了通过体积渲染（VR）技术对美尼尔氏病的淋巴积液进行体积可视化，鼓膜内注射Gd后具有真实重建（3D-真实IR）序列的三维（3D）反转恢复（IR）序列-DTPA使用3T的32通道头线圈进行了优化，以实现更高的空间分辨率。材料与方法：使用稀释的Gd-DTPA体模优化了脉冲序列参数。然后，对11位临床诊断为梅尼埃病的患者和一名突然听力下降的患者进行了扫描。使用市售3D-VR软件处理图像。处理3D真实的IR数据以生成不同颜色的内淋巴和外周淋巴液体积图像。处理3D-CISS数据以生成总流体体积图像。结果：在保持可比的信噪比（SNR）和扫描时间的同时，体素体积可以从12通道线圈的0.4 x 0.4 x 2 mm（3）减少到0.4 x 0.4 x 0.8 mm（3） ）和32通道线圈。新优化的方案可以使所有美尼尔氏病患者的淋巴结积液平滑，三维可视化。结论：现在，在鼓室内施用Gd-DTPA后，使用优化的3D-real IR序列（32通道头线圈），在3T时，对美尼尔氏病患者进行体积上独立的内/周淋巴间隙可视化是可行的。这将有助于对美尼尔氏病的病理生理学的了解。

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