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首页> 外文期刊>Journal of magnetic resonance imaging: JMRI >Measurement of gas transport kinetics in high-frequency oscillatory ventilation (HFOV) of the lung using hyperpolarized (3)He magnetic resonance imaging.
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Measurement of gas transport kinetics in high-frequency oscillatory ventilation (HFOV) of the lung using hyperpolarized (3)He magnetic resonance imaging.

机译：使用超极化（3）He磁共振成像测量肺部高频振荡通气（HFOV）中的气体传输动力学。

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PURPOSE: To protect the patient with acute respiratory distress syndrome from ventilator associated lung injury (VALI) high-frequency oscillatory ventilation (HFOV) is used. Clinical experience has proven that HFOV is an efficient therapy when conventional artificial ventilation is insufficient. However, the optimal settings of HFOV parameters, eg, tidal volumes, pressure amplitudes and frequency for maximal lung protection, and efficient gas exchange are not established unambiguously. METHODS: In this work magnetic resonance imaging (MRI) with hyperpolarized (3)He was employed to visualize the redistribution of gas within the cadaver pig lung during HFOV. The saturated slice method was used to characterize fast gas kinetics. RESULTS: The strong differences in kinetics were observed for HFOV-driven gas exchange in comparison with diffusive gas transport (apnea). The significant regional and HFOV frequency dependence was detected for washout and gas exchange within the lungs. Gas redistribution was much faster in posterior than in anterior parts of the lungs during HFOV, in contrast to minor differences with an opposite trend observed in apnea. CONCLUSION: The method shows significant potential for visualization and quantification of gas redistribution under HFOV and may help in optimization of the parameters to improve the clinical effect of HFOV for patients.
机译：目的：为了保护患有急性呼吸窘迫综合征的患者免于呼吸机相关性肺损伤（VALI），使用了高频振荡通气（HFOV）。临床经验证明，当常规人工通气不足时，HFOV是一种有效的治疗方法。但是，没有明确确定HFOV参数的最佳设置，例如潮气量，压力幅度和频率，以实现最大程度的肺保护，以及有效的气体交换。方法：在这项工作中，使用超极化的磁共振成像（MRI）（3）他被用来观察HFOV期间尸体猪肺内气体的重新分布。饱和切片法用于表征快速气体动力学。结果：与扩散气体传输（呼吸暂停）相比，HFOV驱动的气体交换动力学差异很大。检测到明显的区域和HFOV频率依赖性，以检查肺内的冲洗和气体交换。 HFOV期间，后部的气体重新分布比肺部的前部要快得多，与细微的差异相反，在呼吸暂停中观察到相反的趋势。结论：该方法显示了在HFOV下气体再分配的可视化和定量化的巨大潜力，并且可能有助于优化参数以改善HFOV对患者的临床效果。

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