Synthesis and antitubercular activity of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes.

Shagufta; Srivastava AK; Sinha S

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Synthesis and antitubercular activity of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes.

机译：二芳氧基甲氧基菲的2-羟基-氨基烷基衍生物的合成和抗结核活性。

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摘要

A series of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes were synthesized from nucleophilic opening of oxirane with different amines. These compounds were evaluated for their antitubercular activity against Mycobacterium tuberculosis H(37)R(v) in vitro and showed MIC in the range of 3.12-25microg/ml.

机译：从环氧乙烷与不同胺的亲核开环反应中合成了一系列的二芳氧基甲氧基菲的2-羟基-氨基烷基衍生物。评估这些化合物在体外对结核分枝杆菌H（37）R（v）的抗结核活性，其MIC在3.12-25microg / ml的范围内。

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《Bioorganic and Medicinal Chemistry Letters》 |2005年第23期|共4页
作者
Shagufta; Srivastava AK; Sinha S;
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正文语种 eng
中图分类基础医学;
关键词
derivatives; Synthesis; /mL;

机译：衍生物;合成;/ mL;

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1. Synthesis and antitubercular activity of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes. [J] . Shagufta, Srivastava AK, Sinha S Bioorganic and Medicinal Chemistry Letters . 2005,第23期

机译：二芳氧基甲氧基菲的2-羟基-氨基烷基衍生物的合成和抗结核活性。
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Synthesis and antitubercular activity of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes.

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