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首页> 外文期刊>Journal of Medical Virology >Identification of genotype 4 hepatitis E virus strains from a patient with acute hepatitis E and farm pigs in Bali, Indonesia.
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Identification of genotype 4 hepatitis E virus strains from a patient with acute hepatitis E and farm pigs in Bali, Indonesia.

机译：从印度尼西亚巴厘岛的一名急性戊型肝炎患者和农场猪身上鉴定出基因型4型戊型肝炎病毒株。

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A previous study revealed that antibodies to hepatitis E virus (HEV) (anti-HEV) are highly prevalent among healthy individuals and farm pigs in Bali, Indonesia, and suggested that HEV infection may occur via zoonosis among Balinese people. However, there were no reports of acute hepatitis E in Bali. To elucidate whether Balinese HEV strains recovered from infected humans and pigs have significant sequence similarity, serum samples obtained from 57 patients (age, mean +/- standard deviation, 31.1 +/- 11.9 years) with sporadic acute hepatitis and from one hundred and one 2- or 3-month-old farm pigs in Bali were tested for anti-HEV and HEV RNA. Among the 57 patients, 2 (3.5%) had high-titer IgM/IgA class anti-HEV antibodies and one of them had detectable HEV RNA (BaliE03-46). Overall, 58 pigs (57.4%) tested positive for anti-HEV, while 5 pigs (5.0%) had detectable HEV RNA. Based on the 412-nucleotide sequence within open reading frame 2, the BaliE03-46 isolate and the 5 swine HEV isolates recovered from the viremic pigs were phylogenetically classified in genotype 4, but were only 77.3-90.8% identical to the genotype 4 HEV isolates reported thus far in China, India, Japan, Taiwan, and Vietnam. The BaliE03-46 isolate of human origin shared high identities of 97.3-98.3% with 4 of the 5 Balinese swine isolates, but differed by 16.1% from the remaining swine isolate. These results suggest that indigenous HEV strains of genotype 4 with marked heterogeneity are circulating in Bali, Indonesia, and that pigs are reservoirs of HEV for Balinese people who have a habit of ingesting uncooked pigs.
机译：先前的一项研究表明，在印度尼西亚巴厘岛的健康个体和农场猪中，戊型肝炎病毒（HEV）（抗-HEV）抗体高度流行，并表明巴厘岛人中可能通过人畜共患病发生戊型肝炎病毒感染。但是，巴厘岛没有关于急性戊型肝炎的报道。为了阐明从感染的人和猪中回收的巴厘人戊型肝炎病毒株是否具有显着的序列相似性，从57例散发性急性肝炎患者和110例患者（年龄，平均+/-标准差，31.1 +/- 11.9岁）中获取了血清样本对巴厘岛2个月或3个月大的猪进行了抗HEV和HEV RNA检测。在这57名患者中，有2名（3.5％）具有高滴度的IgM / IgA类抗HEV抗体，其中一名具有可检测的HEV RNA（BaliE03-46）。总体而言，58头猪（57.4％）检测出抗-HEV阳性，而5头猪（5.0％）具有可检测到的HEV RNA。根据开放阅读框2中的412个核苷酸序列，从病毒血症猪中回收的BaliE03-46分离株和5个猪HEV分离株在系统发育上分类为基因型4，但与基因型4 HEV分离株只有77.3-90.8％相同。迄今在中国，印度，日本，台湾和越南的报道。来自人类的BaliE03-46分离株与5个巴厘岛猪分离株中的4个具有97.3-98.3％的较高同一性，但与其余的猪分离株相差16.1％。这些结果表明，具有显着异质性的基因型4的本地HEV菌株正在印度尼西亚巴厘岛流通，而猪是那些习惯于养育未煮熟猪的巴厘人的HEV储存库。

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