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首页> 外文期刊>Journal of Medical Virology >Identification of interspecies recombination among hepadnaviruses infecting cross-species hosts.
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Identification of interspecies recombination among hepadnaviruses infecting cross-species hosts.

机译：鉴定感染跨物种宿主的嗜肝DNA病毒之间的种间重组。

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摘要

Members of the family Hepadnaviridae are divided into two genera, Orthohepadnavirus (from mammalian) and Avihepadnavirus (from avian). Recombination had been found to occur among human hepatitis B virus (HBV) strains of different genotypes, or between hepadnavirus strains from human and nonhuman primate. To reach a comparatively complete inspection of interspecies recombination events among hepadnavirus strains from various hosts, 837 hepadnavirus complete genome sequences from human and 112 from animals were analyzed by using fragment typing to scan for potential interspecies recombinants. Further bootscanning and phylogenetic analyses of the potential recombinants revealed six genome sequences as interspecies recombinants. Interspecies recombination events were found to occur among HBV strains from human and nonhuman primates, from gibbons of different genera, from chimpanzee and an unknown host, and between two avian hepadnavirus strains from birds of different subfamilies, which was identified for the first time. HBV interspecies recombinants were found to have recombination hot spots similar to that of human HBV intergenotype recombinants, breakpoints frequently locating near gene boundaries. Interspecies recombination found in this study may alter current views on hepadnavirus host specificity.
机译：嗜肝DNA病毒科的成员分为两个属，正嗜肝DNA病毒（来自哺乳动物）和狂犬病毒（鸟类）。已经发现重组发生在不同基因型的人类乙型肝炎病毒（HBV）株之间，或在人类和非人类灵长类的嗜肝DNA病毒株之间。为了对来自各个宿主的嗜肝DNA病毒株之间的种间重组事件进行比较完整的检查，使用片段分型法扫描潜在的种间重组体，分析了来自人类的837个嗜肝DNA完整基因组序列和来自动物的112个嗜肝DNA完整基因组序列。对潜在重组子的进一步引导和系统发育分析揭示了作为种间重组子的六个基因组序列。发现首次在人类和非人类灵长类动物，不同属长臂猿，黑猩猩和未知寄主的HBV株之间以及在不同亚科鸟类的两种禽嗜肝DNA病毒株之间发生种间重组事件。发现HBV种间重组体具有与人HBV基因型重组体相似的重组热点，断点经常位于基因边界附近。在这项研究中发现的种间重组可能会改变目前对嗜肝DNA病毒宿主特异性的看法。

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