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首页> 外文期刊>Journal of Medical Virology >Analysis of the full-length genomes of novel hepatitis B virus subgenotypes C11 and C12 in Papua, Indonesia.
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Analysis of the full-length genomes of novel hepatitis B virus subgenotypes C11 and C12 in Papua, Indonesia.

机译：印度尼西亚巴布亚新型乙型肝炎病毒亚型C11和C12的全长基因组分析。

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摘要

Two novel subgenotypes (C6 and D6) of hepatitis B virus (HBV) were identified recently in Papua, a multiethnic area of Indonesia. To characterize further the HBV strains in Papua, serum samples collected from 59 viremic subjects (44 males and 15 females; mean age: 30.0 +/- 15.5 years) among indigenous inhabitants in Papua, were subjected to phylogenetic analysis of an 1.6-kb partial sequence. Forty-five samples (76%) had genotype C HBV (HBV/C) [C5 (n = 1), C6 (n = 40), and unclassifiable (n = 4)], while seven samples (12%) were HBV/D [D1 (n = 1) and D6 (n = 6)] and six samples (10%) were HBV/B [B2 (n = 1), B3 (n = 3), B7 (n = 1), and B8 (n = 1)]; the remaining sample possessed B3 and C6. An analysis of the full-length sequence of the four HBV/C isolates (NMB09122, NMB09124, NMB09075, and MRK89073) that were unclassifiable into any of the 10 known HBV/C subgenotypes (C1-C10) showed no significant evidence of recombination. Over the entire genome, the NMB09122 and NMB09124 isolates shared 99.8% identity and segregated into a cluster with a bootstrap value of 100%, differing from HBV/C1-HBV/C10 by 3.8-6.9% (mean, >/=4.0%), indicating that NMB09122 and NMB09124 can be classified into a novel subgenotype within genotype C (tentatively designated C11). The NMB09075 and MRK89073 isolates were 97.4% identical to each other and differed from known HBV/C isolates, including the C11 strains, by 4.0-7.2% (mean, >/=4.5%) over the entire genome, indicating that NMB09075 and MRK89703 can be classified into another novel HBV/C subgenotype (C12). The distribution of C11 and C12 seemed to be associated with particular language speakers in Papua.
机译：最近在印度尼西亚的多民族地区巴布亚发现了两种新的乙型肝炎病毒亚型（C6和D6）。为了进一步表征巴布亚的HBV病毒株，对巴布亚土著居民中59例病毒血症受试者（44例男性和15例女性;平均年龄：30.0 +/- 15.5岁）收集的血清样本进行了1.6 kb部分顺序。 45个样本（76％）的基因型为C HBV（HBV / C）[C5（n = 1），C6（n = 40）和无法分类的（n = 4）]，而七个样本（12％）为HBV / D [D1（n = 1）和D6（n = 6）]和六个样本（10％）为HBV / B [B2（n = 1），B3（n = 3），B7（n = 1），和B8（n = 1）];其余样品具有B3和C6。对无法分类为10种已知HBV / C亚基因型（C1-C10）的任何一种的四种HBV / C分离株（NMB09122，NMB09124，NMB09075和MRK89073）的全长序列的分析显示，没有明显的重组证据。在整个基因组中，NMB09122和NMB09124分离株具有99.8％的同一性，并分离成一个具有100％引导值的簇，与HBV / C1-HBV / C10的差异为3.8-6.9％（平均值，> / = 4.0％） ，表示可以将NMB09122和NMB09124分类为基因型C（暂定为C11）内的一个新的亚基因型。 NMB09075和MRK89073分离株彼此同源性为97.4％，与已知的HBV / C分离株（包括C11毒株）在整个基因组中的差异为4.0-7.2％（平均值，> / = 4.5％），表明NMB09075和MRK89703可以分为另一种新的HBV / C亚型（C12）。 C11和C12的分布似乎与巴布亚的特定语言使用者有关。

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