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首页> 外文期刊>Journal of Medical Virology >Respiratory viruses in children admitted to hospital intensive care units: evaluating the CLART(R) Pneumovir DNA array.
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Respiratory viruses in children admitted to hospital intensive care units: evaluating the CLART(R) Pneumovir DNA array.

机译：住院重症监护病房儿童的呼吸道病毒：评估CLART®肺活量DNA阵列。

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摘要

Viruses play a significant part in children's respiratory infections, sometimes leading to hospitalization in cases of severe respiratory distress. The aim of this study was to investigate respiratory infections in children treated in a hospital intensive care unit (ICU). Assays were performed using the CLART(R) Pneumovir DNA array assay (Genomica, Coslada, Madrid, Spain), which makes it possible to detect 11 genus of respiratory viruses simultaneously. During the winter of 2008-2009, 73 respiratory specimens collected from 53 children under 2 years of age and admitted to an ICU were tested. At least one virus was detected in 78% (57/73) of the samples. The virological diagnosis was based on single infections in 65% (37/57) and on multiple infections in 35% (20/57) of cases. The array assay revealed respiratory syncytial virus (RSV) in 73.6% (42/57) of the samples and rhinovirus in 24.6% (14/57), either on their own or in co-infections. All viruses identified in single and multiple infections were tested, taking into account clinical features, risk factors, and severity criteria. Children with no risk factors presented more multiple infections, up to 42% of cases, than children with at least one risk factor. RSV seemed to induce severe symptoms by itself as no difference in intubation needs was observed when RSV was detected on its own or in co-infection. The CLART(R) Pneumovir DNA array was useful for examining severe viral respiratory infections, when other viruses than those detected by conventional methods could be involved, particularly in an ICU.
机译：病毒在儿童呼吸道感染中起重要作用，严重的呼吸窘迫病例有时会导致住院。这项研究的目的是调查在医院重症监护室（ICU）治疗的儿童的呼吸道感染。使用CLART Pneumovir DNA阵列测定法（Genomica，Coslada，马德里，西班牙）进行测定，这使得可以同时检测11种呼吸道病毒。在2008-2009年冬季，对从53名2岁以下儿童中收集并入ICU的73份呼吸道标本进行了测试。在78％（57/73）的样本中至少检测到一种病毒。病毒学诊断基于65％（37/57）的单次感染和35％（20/57）的多发感染。阵列检测显示，在样本中有73.6％（42/57）有呼吸道合胞病毒（RSV），在合并感染时有24.6％（14/57）有鼻病毒。考虑到临床特征，危险因素和严重性标准，对在一次或多次感染中发现的所有病毒进行了测试。没有危险因素的儿童比具有至少一种危险因素的儿童发生多发感染，占病例的42％。 RSV似乎本身会引起严重的症状，因为在单独或共同感染时检测到RSV时未观察到插管需求的差异。当除常规方法检测到的其他病毒以外，特别是在ICU中，可能会使用CLART®肺活菌DNA阵列检查严重的病毒性呼吸道感染。

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