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首页> 外文期刊>Journal of Medical Virology >Frequency, clinical characteristics, and genotype distribution of rotavirus gastroenteritis in Greece (2007-2008).
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Frequency, clinical characteristics, and genotype distribution of rotavirus gastroenteritis in Greece (2007-2008).

机译：希腊轮状病毒胃肠炎的发生频率，临床特征和基因型分布（2007-2008年）。

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摘要

Rotavirus is the leading cause of acute gastroenteritis among young children worldwide. A prospective multi-center study was conducted (2007-2008) in five Pediatric Hospitals to determine the prevalence, the clinical characteristics, and genotype distribution of rotavirus infection in Greece. Faecal samples were examined for the presence of group A rotavirus antigen by immunochromatography. Rotavirus strains were subjected to G and P genotyping by reverse-transcriptase polymerase chain reaction (PCR) and sequencing. A total of 393 children (216 boys) of median age 23 months, participated in the study. Rotavirus was the cause of acute gastroenteritis in 166 children, 42.3% (CI 95%, 37.4-47.1%) of non-hospitalized and 47.8% (CI 95%, 41.7-53.9%) of hospitalized patients. Rotavirus gastroenteritis occurred between December and April in 78.6% of the cases. Most children with RVG (77.8%) were between 3 months and 3 years old. The mean value of Clark severity score was 12.9 +/- 5.1 for RVG and 10.5 +/- 4.9 for non-RVG (P < 0.01). Genotypes were determined in 117 strains and their distribution was as following: G1P[8], 49%; G2P[4], 31%; G4P[8], 10%; G9P[8], 9%; and G8P[14], 1%. In conclusion, rotavirus is a frequent cause of acute gastroenteritis in Greece. The genotypes circulating are similar with those of other European countries.
机译：轮状病毒是全球幼儿急性肠胃炎的主要原因。在希腊的五家儿科医院中进行了一项前瞻性多中心研究（2007-2008年），以确定轮状病毒感染的患病率，临床特征和基因型分布。通过免疫色谱法检查粪便样品中是否存在A组轮状病毒抗原。通过逆转录酶聚合酶链反应（PCR）和测序对轮状病毒菌株进行G和P基因分型。共有393名中位数23个月的儿童（216名男孩）参加了这项研究。轮状病毒是166例儿童急性肠胃炎的病因，其中42.3％（CI 95％，37.4-47.1％）的非住院患者和47.8％（CI 95％，41.7-53.9％）的住院患者。轮状病毒肠胃炎发生在12月至4月之间，占78.6％。大多数RVG儿童（77.8％）在3个月至3岁之间。 RVG的Clark严重性评分平均值为12.9 +/- 5.1，非RVG的平均值为10.5 +/- 4.9（P <0.01）。确定了117个菌株的基因型，其分布如下：G1P [8]，49％; G2P [4]，31％; G4P [8]，10％; G9P [8]，9％; G8P [14]为1％。总之，轮状病毒是希腊急性胃肠炎的常见原因。传播的基因型与其他欧洲国家相似。

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