...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Medical Virology >A prospective longitudinal study of BK virus infection in 120 Czech renal transplant recipients.
【24h】

A prospective longitudinal study of BK virus infection in 120 Czech renal transplant recipients.

机译：前瞻性纵向研究BK病毒感染120捷克肾移植受者。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Polyomavirus BK (BKV) is a common human polyomavirus that rarely causes clinical symptoms in immunocompetent individuals. However, BK virus reactivation occurs in 20-40% of kidney transplant patients and 1-10% of cases present with BK virus-associated nephropathy (BKVN) and reduced kidney allograft survival. In this study, 120 consecutive renal allograft recipients were monitored for BK virus replication by real-time PCR (qPCR) in the blood and urine during the first year post-transplantation and risk factors for BK viremia, viruria, and polyoma BKV-associated nephropathy were evaluated. Receiver operating characteristic curve analysis was used to determine the cutoff points for assessing the risk of developing BKVN. In total, 1,243 samples were tested. BK-DNAuria >10(7) copies/ml and BK-DNAemia >10(4) copies/ml were found in 25.8% and 5% of the samples screened, respectively, during the 12 month follow-up period. BKVN was confirmed histologically in 3/120 patients and viremic patients were treated with dialysis for longer time periods and had higher levels of anti-BKV-reactive antibodies. Patients with viruria were also treated longer with dialysis and had impaired graft function 12 months post-transplantation. Patients with sustained viruria exhibited more acute rejection episodes than patients with transient viruria. Using receiver operating characteristic curve analysis, the cutoff point for viremia and viruria was redefined to 10(3) copies/ml serum for BK viremia and a cutoff point of 6.7 x 10(7) copies/ml in urine. In conclusion, polyoma BK viremia and viruria are frequent findings in kidney transplant recipients that warrant intensive monitoring as a means of preventing graft rejection.
机译：多瘤病毒BK（BKV）是一种常见的人类多瘤病毒，很少在具有免疫能力的个体中引起临床症状。但是，在20-40％的肾脏移植患者和1-10％的BK病毒相关性肾病（BKVN）病例中，BK病毒会重新激活，并且肾移植的存活率降低。在这项研究中，在移植后的第一年，通过实时PCR（qPCR）监测了120名连续的同种异体肾移植受者的BK病毒复制情况以及BK病毒血症，病毒血症和多瘤BKV相关性肾病的危险因素被评估。接收者的工作特征曲线分析被用来确定临界点，以评估发生BKVN的风险。总共测试了1,243个样品。在12个月的随访期间，分别在筛查的样本中发现BK-DNA尿量> 10（7）个/ ml，BK-DNAemia> 10（4）个/ ml。 BKVN在3/120例患者中在组织学上得到证实，病毒血症患者接受透析治疗的时间更长，并且抗BKV反应性抗体的水平更高。病毒血症患者在移植后12个月也接受了更长的透析治疗，移植物功能受损。持续性尿毒症患者比短暂性尿毒症患者表现出更多的急性排斥反应。使用接收器工作特征曲线分析，将BK病毒血症的病毒血症和病毒血症的临界点重新定义为10（3）拷贝/ ml血清，尿中的临界点重新定义为6.7 x 10（7）拷贝/ ml。总之，在肾移植受者中经常发现多瘤BK病毒血症和病毒血症，应加强监测以预防移植物排斥。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号