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首页> 外文期刊>Journal of Medical Virology >Aboriginal Taiwanese hepatitis B carriers have more favorable viral factors than Han Chinese carriers.
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Aboriginal Taiwanese hepatitis B carriers have more favorable viral factors than Han Chinese carriers.

机译：台湾原住民乙型肝炎携带者比汉族携带者具有更有利的病毒因素。

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摘要

Several viral factors are associated with disease progression in hepatitis B virus (HBV) carriers. Compared with Taiwanese Han Chinese, Taiwanese aborigines have a higher prevalence of chronic HBV infection and a higher standardized mortality rate of chronic liver diseases but a lower standardized mortality rate of hepatocellular carcinoma (HCC). The aim of this study was to investigate whether aboriginal Taiwanese HBV carriers have more favorable viral factors which reduce the risk for HCC than Han Chinese carriers. Blood samples from 3,488 HBV carriers (1,527 aborigines and 1,961 Han Chinese) were assayed for aminotransferases, hepatitis B e antigen (HBeAg), HBV DNA, and HBV genotype. Aboriginal HBV carriers had a lower HBeAg-positive rate (5.3% vs. 10.2%, P < 0.0001) and a lower viral load of HBV DNA > 2,000 IU/ml (27.4% vs. 36.7%, P < 0.0001) but a higher rate of alcohol consumption (40.0% vs. 19.3%, P < 0.0001) than Han Chinese carriers. The prevalence of HBV genotype B in aboriginal carriers (92.7%) was significantly higher than that in Han Chinese carriers (72.7%) in all age groups (P < 0.05). In addition, patients with rare genotype D infections were clustered in a township in southern Taiwan. In conclusion, aboriginal Taiwanese HBV carriers have more favorable viral factors than Han Chinese carriers, which may be partly responsible for the lower standardized mortality rate of HCC in Taiwanese aborigines.
机译：几种病毒因素与乙型肝炎病毒（HBV）携带者的疾病进展有关。与台湾汉族人相比，台湾原住民的慢性HBV感染患病率更高，慢性肝病的标准化死亡率更高，但是肝细胞癌（HCC）的标准化死亡率更低。这项研究的目的是调查台湾原住民的HBV携带者是否比汉族携带者具有更有利的病毒因素，从而降低了患HCC的风险。对来自3,488例HBV携带者（1,527名原住民和1,961汉族）的血样进行了氨基转移酶，乙型肝炎e抗原（HBeAg），HBV DNA和HBV基因型的检测。土著HBV携带者的HBeAg阳性率较低（5.3％对10.2％，P <0.0001），HBV DNA病毒载量> 2,000 IU / ml较低（27.4％对36.7％，P <0.0001），但较高饮酒率（40.0％对19.3％，P <0.0001）高于汉族携带者。在所有年龄组中，原住民携带者中HBV基因型B的患病率（92.7％）显着高于汉族携带者（72.7％）（P <0.05）。此外，罕见的D型基因感染患者聚集在台湾南部的一个小镇。总之，台湾原住民HBV携带者比汉族携带者具有更有利的病毒因素，这可能部分归因于台湾原住民的HCC标准化死亡率较低。

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