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首页> 外文期刊>Journal of Medical Virology >Decreased expression of surfactant protein D mRNA in human lungs in fatal cases of H5N1 avian influenza.
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Decreased expression of surfactant protein D mRNA in human lungs in fatal cases of H5N1 avian influenza.

机译：在致命的H5N1禽流感病例中，肺中表面活性剂蛋白D mRNA的表达降低。

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Microarray analysis of gene expression profile of lungs from two fatal H5N1 influenza cases identified 3,435 genes with higher than twofold changes in mRNA levels as compared to those of normal lung. One thousand nineteen genes and 2,416 genes were up-regulated and down-regulated commonly, respectively. Gene ontology analysis identified several ontology terms with significant association with these genes, most of which are related to cellular metabolism and regulation of cellular process including apoptosis and chemotaxis. Pulmonary surfactant protein D (SP-D) was found to be down-regulated. Quantitative RT-PCR confirmed the levels of SP-D mRNA in the lungs infected with H5N1 to be lower than those of normal lungs and lungs from patients with acute respiratory distress syndrome. SP-D plays multiple roles in respiratory innate defense against various pathogens, regulation of inflammatory responses, and maintenance of alveolar integrity. Reduction of SP-D in H5N1 influenza may play important roles in the pathogenesis of the disease.
机译：基因芯片分析了两个致命的H5N1流感病例的肺的基因表达谱，鉴定出3435个基因的mRNA水平比正常肺的基因水平高出两倍。分别分别上调和下调了119个基因和2416个基因。基因本体分析确定了几个与这些基因有显着关联的本体术语，其中大多数与细胞代谢和细胞过程包括细胞凋亡和趋化性的调节有关。发现肺表面活性蛋白D（SP-D）被下调。定量RT-PCR证实感染H5N1的肺中SP-D mRNA水平低于正常肺和患有急性呼吸窘迫综合征患者的肺中SP-D mRNA水平。 SP-D在针对各种病原体的呼吸先天防御，调节炎症反应以及维持肺泡完整性方面发挥着多种作用。 H5N1流感中SP-D的减少可能在疾病的发病机理中起重要作用。

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