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首页> 外文期刊>Journal of Medical Virology >Fifteen years of env C2V3C3 evolution in six individuals infected clonally with human immunodeficiency virus type 1.
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Fifteen years of env C2V3C3 evolution in six individuals infected clonally with human immunodeficiency virus type 1.

机译：env C2V3C3进化十五年的六个人克隆感染了1型人类免疫缺陷病毒。

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摘要

The study of the evolution of human immunodeficiency virus type 1 (HIV-1) requires blood samples collected longitudinally and data on the approximate time point of infection. Although these requirements were fulfilled in several previous studies, the infectious sources were either unknown or heterogeneous genetically. In the present study, HIV-1 env C2V3C3 (nt 7029-7315) evolution was examined retrospectively in a cohort of hemophiliacs. Compared to other cohorts, the area of interest here was the infection of six hemophiliacs by the same virus strain, that is, the infecting viruses shared an identical genome. As expected, divergence from the founder sequence as well as interpatient divergence of the predominant virus strains increased significantly over time. Based on the V3 nucleotide sequences, CCR5 usage was predicted exclusively throughout the whole period of infection in all patients. Interestingly, common patterns of viral evolution were detected in the patients of the cohort. Four amino acid substitutions within the V3 loop emerged and persisted subsequently in five (positions 305 and 308 of the HXB2 gp120 reference sequence) and six patients (positions 325 and 328 in HXB2 gp120), respectively. These common changes within the V3 loop are likely to be enforced by HIV-1 specific immune response.
机译：对人类1型免疫缺陷病毒（HIV-1）进化的研究需要纵向收集血液样本并提供有关感染的大致时间点的数据。尽管先前的几项研究都满足了这些要求，但传染源在遗传上还是未知的或异质的。在本研究中，回顾性研究了一组血友病患者的HIV-1 env C2V3C3（nt 7029-7315）进化。与其他同类人群相比，此处的关注领域是同一病毒株感染了六个血友病患者，也就是说，感染病毒共享相同的基因组。正如预期的那样，主要病毒株与创始人序列的差异以及患者之间的差异随着时间的推移显着增加。根据V3核苷酸序列，仅在所有患者的整个感染期间都预测使用CCR5。有趣的是，在该队列患者中检测到了常见的病毒进化模式。 V3环内出现了四个氨基酸取代，并随后分别在五个（HXB2 gp120参考序列的305和308位）和六位患者（HXB2 gp120的325和328位）中持续存在。 V3回路内的这些常见变化很可能是由HIV-1特异性免疫反应引起的。

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