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首页> 外文期刊>Journal of Medical Virology >Nationwide surveillance of 18 respiratory viruses in patients with influenza-like illnesses: a pilot feasibility study in the French Sentinel Network.
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Nationwide surveillance of 18 respiratory viruses in patients with influenza-like illnesses: a pilot feasibility study in the French Sentinel Network.

机译：全国流感样疾病患者中18种呼吸道病毒的监测：法国哨兵网络的可行性试验研究。

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The aim of the present study was to test the feasibility of integrating the diagnosis of 18 respiratory viruses into clinical surveillance of influenza-like illness using a PCR-DNA microarray detection assay. The study took place in the French Sentinel Network, a nationwide surveillance network of General Practitioners (GPs) representative of French GPs in terms age, location, and type of practice (urban/rural). Three virological laboratories also participated in the study. The study was planned for 5 weeks from January 25, 2010 to February 27, 2010. A subset of 150 Sentinel GPs, located in mainland France, was enrolled to collect clinical data and nasopharyngeal samples from every first patient of the week having a medical visit for influenza-like illness defined as a sudden fever of 39 degrees C or more with respiratory symptoms and myalgia. Sixty-three GPs (42%) collected 103 samples while 87 GPs (58%) did not. GPs did not differ with respect to their age, gender, urban/rural distribution, or years of inscription in the Sentinel Network. Patients included were of a similar age and had similar vaccination characteristics, but were more frequently men than influenza-like illness patients reported to the network during the study period. Sixty-one viruses were detected from 56 of 96 (58%) interpretable samples. The respiratory viruses detected most frequently were metapneumovirus and respiratory syncytial virus. This study showed that virological diagnosis of 18 respiratory viruses can be combined with surveillance of clinical influenza-like illness in general practice. Although feasibility has not been demonstrated yet, it will be evaluated over the winter of 2010-2011.
机译：本研究的目的是检验使用PCR-DNA芯片检测方法将18种呼吸道病毒的诊断整合到流感样疾病的临床监测中的可行性。这项研究是在法国哨兵网络中进行的，该网络是法国全科医生在年龄，地点和执业类型（城市/农村）方面的全国性监视网络。三个病毒学实验室也参加了这项研究。该研究计划于2010年1月25日至2010年2月27日进行，为期5周。该研究包括了150个Sentinel GP的子集，它们位于法国大陆，旨在从一周内就诊的第一位患者收集临床数据和鼻咽样本适用于流感样疾病，定义为39摄氏度或更高的突然发烧，并伴有呼吸道症状和肌痛。 63个GP（42％）收集了103个样本，而87个GP（58％）没有收集。 GP的年龄，性别，城市/农村分布或在Sentinel网络中的登记年限没有差异。在研究期间，入组患者的年龄相似且具有相似的疫苗接种特征，但男性发病率高于向网络报告的流感样疾病患者。从96个可解释样本中的56个（58％）中检测到61个病毒。最常检测到的呼吸道病毒是间质肺病毒和呼吸道合胞病毒。这项研究表明，在一般情况下，可以将18种呼吸道病毒的病毒学诊断与临床流感样疾病的监测相结合。尽管尚未证明可行性，但将在2010-2011年冬季进行评估。

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