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首页> 外文期刊>Journal of Medical Virology >Naturally occurring hepatitis B virus X deletions and insertions among Korean chronic patients.
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Naturally occurring hepatitis B virus X deletions and insertions among Korean chronic patients.

机译：韩国慢性患者中自然发生的乙型肝炎病毒X缺失和插入。

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Deletions and insertions in the hepatitis B virus (HBV) X region have been associated with severe forms of liver disease, including hepatocellular carcinoma (HCC). However, the molecular epidemiologic features of this virus have been described rarely. Deletions and insertions in the X region were determined by direct sequencing in a Korean cohort of 267 patients with different clinical statuses. Deletions and insertions were observed in two sets of six patients each (2.2%, 6/267). The prevalence of deletions or insertions was significantly higher in patients with severe liver disease, HCC, or cirrhosis of the liver (7.2%, 10/132) compared to patients who were carriers or had chronic hepatitis (1.5%, 2/135) (P = 0.017). All deletions in six strains were concentrated at the C terminal end of HBx, encompassing the 113th to 154th codons. A total of four novel types of insertions (PKLL, GM, FFN, and tt) were observed in six patients. Of particular interest, all six strains with insertions were accompanied by double mutations in the basal core promoter (BCP). In conclusion, these results suggest that deletions or insertions in the X region may contribute to disease progression in Korean patients with genotype C infection.
机译：乙型肝炎病毒（HBV）X区的缺失和插入与包括肝细胞癌（HCC）在内的严重肝病有关。但是，很少描述这种病毒的分子流行病学特征。在韩国地区的267名具有不同临床状况的患者队列中，通过直接测序确定了X区的缺失和插入。在两组中各有6位患者中观察到缺失和插入（2.2％，6/267）。与携带者或患有慢性肝炎的患者（1.5％，2/135）相比，患有严重肝病，HCC或肝硬化的患者中缺失或插入的发生率显着更高（7.2％，10/132）（ P = 0.017）。六个菌株中的所有缺失都集中在HBx的C末端，涵盖第113至154个密码子。在六位患者中总共观察到四种新颖的插入类型（PKLL，GM，FFN和tt）。特别令人感兴趣的是，所有六个带有插入片段的菌株在基底核心启动子（BCP）中均伴有双重突变。总之，这些结果表明，在X区缺失或插入可能会导致C基因型韩国感染患者的疾病进展。

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